Guard Column Starter Set, UDC Cholesterol, complete with 5 each 2.0 mm ID x 10 mm long cartridges packed with 4 um, 100 A phase and 1 each guard column holder. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 69069‑PG1 Cogent UDC‑Cholesterol Guard Column Starter Set provides a complete protection system for analytical HPLC columns, helping extend column lifetime while maintaining unique shape‑selective performance.
This starter kit includes:
(5) UDC‑Cholesterol guard cartridges
2.0 mm ID × 10 mm length
Packed with 4 µm, 100 Å TYPE‑C™ silica hydride UDC‑Cholesterol phase
Each cartridge is supplied in an individual protective Delrin™ case, preventing contamination, drying, and damage before use.
The holder is compatible with all Cogent TYPE‑C™ guard cartridges, offering flexibility across methods and stationary phases.
Designed for 2.1 mm Analytical Columns
This starter kit is optimized for:
2.1 mm ID analytical HPLC columns
LC‑MS and low‑flow workflows
High‑sensitivity analytical methods
Proper guard column integration ensures:
Minimal band broadening
Maintained efficiency and resolution
Consistent chromatographic performance
Why Use a Guard Column Starter Kit
Analytical columns are vulnerable to:
Particulates and debris
Strongly retained compounds
Complex sample matrix buildup
Irreversible adsorption
The 69069‑PG1 starter kit acts as a sacrificial protection layer, helping to:
Extend analytical column lifetime significantly
Maintain consistent method performance
Reduce replacement frequency and cost
Improve reproducibility across runs
Under typical use, the five included cartridges often provide protection for the lifetime of an analytical column, depending on sample cleanliness.
UDC‑Cholesterol™ Guard Phase Advantages
Using a guard column with the same stationary phase ensures:
Matched shape selectivity and retention behavior
No disruption to analytical method performance
Seamless analyte transfer to the analytical column
Unique Shape‑Selective Interaction
Separates analytes based on 3D structure and steric fit
Ideal for isomers and structurally similar compounds
Strong Hydrophobic Interaction
Effective retention of lipids and hydrophobic analytes
Tunable Selectivity
Selectivity can be adjusted using:
Temperature changes
Mobile phase composition
Cogent TYPE‑C™ Technology Benefits
Silica Hydride Surface
Direct Si–C bonding (no end‑capping required)
Reduced silanol interactions
Improved peak shape for basic and polar analytes
Faster Equilibration
Reduced run‑to‑run cycle time
Increased analytical throughput
Durability
Resistant to hydrolysis
Long guard cartridge and column lifetime
Stable under demanding analytical conditions
Typical Applications
LC‑MS analytical methods
Steroidal compound analysis
Structural isomer separations
Lipids and hydrophobic analytes
Peptides, proteins, and oligonucleotides
Methods requiring shape selectivity protection