Guard Column cartridge, UDC Cholesterol, replacement, 2.0 mm ID x 10 mm long cartridge packed with 4 um, 100 A phase. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 69069‑PG3 Cogent UDC‑Cholesterol Guard Column Cartridge is a single replacement cartridge designed to protect analytical HPLC columns while preserving the unique shape‑selective performance of the UDC‑Cholesterol stationary phase.
Each cartridge is:
2.0 mm ID × 10 mm length
Packed with 4 µm, 100 Å TYPE‑C™ silica hydride UDC‑Cholesterol phase
Constructed in stainless steel housing with SS frits
The cartridge is supplied in an individual protective Delrin™ case, preventing contamination, drying, or physical damage prior to use.
⚠️ Requires guard column holder (sold separately)
Designed for 2.1 mm Analytical Columns
This cartridge is optimized for:
2.1 mm ID analytical HPLC columns
LC‑MS and low‑flow workflows
High‑sensitivity analytical applications
Proper guard column matching ensures:
Minimal peak dispersion
Maintained efficiency and resolution
Consistent retention and selectivity
Why Use a Single Guard Cartridge
A single‑cartridge configuration is ideal when:
Testing different guard phases during method development
Running multiple analytical methods with different selectivities
Replacing cartridges individually as needed
Avoiding bulk purchases while maintaining protection
This format provides maximum flexibility for method optimization.
Why Use Guard Column Protection
Analytical columns are exposed to:
Particulates and system contaminants
Strongly retained or irreversible analytes
Matrix buildup from complex samples
Progressive column fouling
The 69069‑PG3 cartridge acts as a sacrificial protection layer, helping to:
Extend analytical column lifetime significantly
Maintain chromatographic performance
Reduce downtime and replacement costs
Improve reproducibility across analyses
Cartridges can be replaced quickly without disturbing the analytical column setup.
UDC‑Cholesterol™ Guard Phase Advantages
Using the same stationary phase as your analytical column ensures:
Matched shape selectivity and retention behavior
No disruption to method performance
Seamless analyte transfer to the main column
Shape‑Selective Interaction
Separates compounds based on 3D molecular structure and steric fit
Ideal for isomers and closely related molecules
Strong Hydrophobic Retention
Effective for lipids and hydrophobic analytes
Enhances retention of difficult compounds
Tunable Selectivity
Adjust separations using:
Temperature changes
Mobile phase composition
Cogent TYPE‑C™ Technology Benefits
Silica Hydride Surface
Direct Si–C bonding (no end‑capping required)
Reduced silanol interactions
Improved peak shape for basic and polar analytes
Faster Equilibration
Reduced run‑to‑run cycle times
Increased analytical throughput
Durability
Resistant to hydrolysis
Long cartridge and column life
Stable under demanding analytical conditions
Typical Applications
LC‑MS analytical methods
Steroidal compound analysis
Structural isomer separations
Lipids and hydrophobic analytes
Peptides, proteins, and oligonucleotides
Methods requiring shape‑selectivity protection