Catalog Number - 69020-PG1

Phenyl Hydride™ Guard Column Starter Set for Analytical Column Protection

The 69020‑PG1 Phenyl Hydride™ Guard Column Starter Set provides a complete, ready‑to‑use solution for protecting analytical Phenyl Hydride™ HPLC columns from particulate contamination and strongly retained sample components. Designed around Cogent TYPE‑C™ silica hydride technology, this starter set helps preserve chromatographic performance, maintain consistent retention, and extend the usable lifetime of analytical columns in routine HILIC workflows.

Guard columns are strongly recommended when working with complex samples or high injection counts, where column protection is critical to long‑term method reliability.

What’s Included in the Starter Set

This comprehensive starter kit includes:

• Stainless Steel Guard Cartridge Column Holder Precision‑manufactured for secure, low‑dead‑volume installation upstream of the analytical column. The holder is compatible with Cogent TYPE‑C™ guard cartridges.

• Five Phenyl Hydride™ Guard Cartridges Each cartridge is packed with 4 µm, 100 Å Phenyl Hydride™ stationary phase, matched to analytical Phenyl Hydride columns to ensure consistent selectivity and retention behavior.

Each guard cartridge is shipped in an individual, closeable Delrin® storage case to prevent drying, contamination, or physical damage prior to use.

Why Use Phenyl Hydride™ Guard Columns

Using a matched guard cartridge provides several important benefits:

• Protects analytical columns from particulates and irreversibly adsorbed contaminants

• Preserves peak shape, retention stability, and column efficiency

• Extends analytical column lifetime and reduces replacement costs

• Supports reproducible performance over extended analytical sequences

Under typical laboratory conditions, the included cartridges are often sufficient to protect an analytical column for the majority of its service life.

Phenyl Hydride™ Stationary Phase Consistency

The guard cartridges in this set are packed with the same Phenyl Hydride™ stationary phase chemistry used in analytical columns, ensuring:

• No change in chromatographic selectivity or elution order

• Minimal added dead volume

• Seamless integration into existing HILIC methods

• Stable retention under high‑organic mobile‑phase conditions

This consistency is essential for maintaining method integrity when guard protection is added.

Intended Use and Compatibility

The 69020‑PG1 Guard Column Starter Set is designed for use with:

• 2.1 mm ID analytical Phenyl Hydride™ columns

• HILIC‑mode analytical HPLC and LC‑MS workflows

• Conventional HPLC and UHPLC systems capable of stable low‑flow delivery

The guard column holder installs directly upstream of the analytical column.

Guard Cartridge Replacement Guidance

Guard cartridges should be replaced when:

• System backpressure increases

• Peak shape begins to degrade

• Retention behavior changes

• Sample matrix complexity increases

Routine replacement ensures continued protection and consistent analytical performance.