Guard Column Starter Set, Diamond Hydride, complete with 5 each 2.0 mm ID x 10 mm long cartridges packed with 4 um, 100 A phase and 1 each guard column holder. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 70000‑PG1 Diamond Hydride Guard Column Starter Set is designed to protect analytical HPLC columns from particulate contamination, strongly retained compounds, and matrix interferences that can degrade performance and shorten column lifetime.
This complete starter set provides everything required to implement a proper guard‑column strategy for Cogent TYPE‑C™ Diamond Hydride analytical methods—without altering chromatographic selectivity, retention, or efficiency.
Guard Column Use Case: Protecting the Analytical Separation
Guard columns are installed upstream of the analytical column and serve as a sacrificial bed that captures contaminants before they reach the analytical stationary phase.
Critical Requirement: To preserve chromatographic fidelity, the stationary phase in the guard cartridge must match the stationary phase of the analytical column.
The Diamond Hydride guard cartridges included in this set ensure:
No change in retention mechanism
No loss of resolution
No shift in selectivity
No peak distortion or method drift
Using a guard cartridge with a different chemistry will compromise the separation and can invalidate analytical results.
What’s Included in This Starter Set
This kit includes all components required to begin using Cogent TYPE‑C™ guard columns:
Stainless Steel Guard Cartridge Holder
Precision‑machined stainless steel construction
Compatible with all Cogent TYPE‑C™ guard cartridges
Designed for reliable, leak‑free performance under analytical HPLC pressures
Five Diamond Hydride Guard Cartridges
2.0 mm ID × 10 mm length
Packed with Diamond Hydride, 4 µm, 100 Å stationary phase
Provides sufficient protection for the typical lifetime of an analytical column under average use conditions
Each cartridge is shipped in an individual resealable Delrin case to prevent drying or damage
Analytical Column Compatibility
This guard column system is intended for use with:
2.1 mm ID analytical HPLC columns
Cogent TYPE‑C™ Diamond Hydride analytical columns
HILIC and LC‑MS workflows where retention mechanism stability is critical
Matching stationary phases between guard and analytical columns is essential to maintain reproducibility, resolution, and regulatory confidence.
Guard Column Installation Best Practices
To preserve chromatographic efficiency, the guard column must be installed as close to the analytical column inlet as physically possible.
Minimizing the distance between the guard holder and the analytical column reduces extra‑column (dead) volume, which is especially important for high‑efficiency HILIC and LC‑MS separations. Excess tubing length or poorly positioned fittings can lead to:
Band broadening
Loss of theoretical plates
Reduced resolution
Peak tailing or distortion
When installed immediately upstream of the analytical column and paired with a matching Diamond Hydride stationary phase, the guard column functions as a true sacrificial bed while preserving the integrity of the analytical separation.
Purpose‑Built for Method Protection & Column Longevity
The 70000‑PG1 guard column system is commonly used in:
Method development laboratories
Routine analytical and QC environments
LC‑MS and HILIC workflows
Regulated labs where column performance must remain consistent
Proper use of guard columns can significantly extend analytical column lifetime, reduce downtime, and improve long‑term method reproducibility.
System Requirements
Compatible with standard analytical HPLC systems
Installed between injector and analytical column
No method changes required when stationary phases are properly matched