HPLC Column, RP C18 PE, 5um, 4.6mm ID x 50mm Length, 100A. Cogent RP Brand. 1 EA.
Additional Info:
The 84518‑05P Cogent RP C18 PE™ HPLC Column is designed for fast, robust analytical separations, utilizing 5 µm particles with a polar embedded amide group within a C18 ligand to provide enhanced retention of polar compounds and stable reversed‑phase performance.
Manufactured on high‑purity silica with fully double end‑capped bonding, this stationary phase delivers:
Reduced silanol interactions
Improved peak shape for polar and basic analytes
Stable retention in high aqueous mobile phases, including 100% water
The embedded amide functionality allows stronger interaction with polar analytes while maintaining hydrophobic selectivity, preventing the phase collapse common with traditional C18 columns.
50 mm Length – Fast Scouting & Method Development
Designed for rapid separations and short cycle times
Ideal for method development and screening workflows
Minimizes solvent consumption
Frequently used for preparative method scouting
4.6 mm ID – Standard Analytical Platform
Compatible with standard HPLC systems
Ideal for:
method development
QC and routine analysis
Provides robust, reproducible analytical performance
Typical Flow Rate Range
~0.8–1.5 mL/min
✅ Suitable for standard analytical systems without special flow requirements
5 µm Particle – Rugged & Reliable Performance
Designed for durability and long column lifetime
Provides reliable performance in routine workflows
Ideal for method transfer and general‑purpose analysis
✅ Preferred when robustness and reproducibility are prioritized over maximum efficiency
Why Choose RP C18 PE™ (Polar Embedded)
Enhanced Polar Retention
Retains polar compounds without phase collapse
Stable in 100% aqueous mobile phases
Improves retention compared to standard C18 columns
Dual‑Mode Flexibility
Operates in:
Reversed Phase (RP)
HILIC‑like modes under appropriate conditions
Ideal for Mixed Polarity Samples
Suitable for:
polar analytes poorly retained on conventional C18
complex mixtures with broad polarity ranges
Enables flexible and robust method development
USP Method Compatibility
Suitable as a USP L1 alternate
Ideal for methods requiring:
high aqueous mobile phases
consistent retention of polar compounds
Typical Applications
Analytical method development
Preparative method scouting
Pharmaceutical QC and testing
Polar and hydrophilic compound separations
Long‑chain fatty acids
Mixed polarity sample analysis
Cogent RP C18 PE™ Advantages
Polar Embedded Ligand
Enhances interaction with polar analytes
Maintains traditional C18 hydrophobic selectivity
Fully End‑Capped Surface
Minimizes secondary interactions
Improves peak symmetry and reproducibility
High Purity Silica
Consistent chromatographic performance
Reliable run‑to‑run results
Important Usage Notes
Ideal for fast analytical screening and method development
Suitable for high aqueous mobile phases (including 100% water)
Compatible with standard 4.6 mm HPLC systems
Optimize depending on RP or mixed‑mode separation requirements