Catalog Number - 84318-PG1

The 84318‑PG1 Cogent RP C18 PE™ Guard Column Cartridges are engineered to extend the life of narrow‑bore LC‑MS and analytical HPLC columns, delivering high‑efficiency protection against particulates, strongly retained compounds, and sample matrix fouling.

Packed with 3 µm Cogent RP C18 PE™ polar embedded stationary phase—featuring an amide group within a C18 ligand—and manufactured on high‑purity silica with full double end‑capping, these cartridges provide:

• Reduced silanol interactions

• Improved peak symmetry for polar and basic analytes

• Stable performance in high aqueous mobile phases, including 100% water

Each cartridge is constructed in a stainless steel tube with stainless steel frits, secured with PEEK frit caps for durability and leak‑free performance in low‑flow systems.

Designed for 2.1 mm ID Columns (LC‑MS / Low Flow)

• Optimized for:

  • 2.1 mm ID LC‑MS columns

  • low‑flow analytical HPLC systems

✅ Maintains chromatographic performance at low flow rates (~0.2–0.3 mL/min) ✅ Ideal for high‑sensitivity LC‑MS applications

Purpose of Guard Columns

• Protect analytical columns from:

  • Particulate contamination

  • Strongly retained polar and non‑polar analytes

  • Matrix buildup and fouling

• Extend column lifetime

• Maintain retention reproducibility and peak shape

• Reduce downtime and replacement costs

3 µm Guard Media – High‑Efficiency Protection

• Matches high‑efficiency analytical and LC‑MS column packings

• Preserves resolution and chromatographic integrity

• Ideal for sensitive analytical and LC‑MS workflows

✅ Ensures minimal impact on efficiency while maximizing protection

Why Choose RP C18 PE™ Guard Cartridges (3 µm)

Matched Polar Embedded Chemistry

• Same PE stationary phase as analytical column

• Maintains polar retention characteristics and selectivity

• Prevents method variability

Enhanced LC‑MS Protection

• Reduces contamination entering the detector and system

• Protects high‑value low‑flow columns and MS interfaces

Workflow Efficiency

• Minimizes column replacement frequency

• Improves analytical system uptime

Cogent RP C18 PE™ Advantages

Polar Embedded Ligand

• Improves interaction with polar analytes

• Maintains traditional C18 hydrophobic selectivity

Fully End‑Capped Surface

• Minimizes secondary interactions

• Enhances reproducibility and peak shape

Precision Construction

• Stainless steel body and frits

• PEEK sealing system

• Designed for low‑flow analytical environments

Important Usage Notes

• ⚠️ Must be used with a compatible guard column holder system

• Designed specifically for 2.1 mm LC‑MS and low‑flow HPLC systems

• Requires precise low‑flow pump and detector compatibility

• Replace regularly to maintain optimal column protection and performance