Catalog Number - 84018-15P

The 84018‑15P Cogent RP C18 PE™ HPLC Column is engineered for robust, high‑resolution analytical method development, utilizing 10 µm particles with a polar embedded amide group within a C18 ligand to deliver stable polar retention and highly durable chromatographic performance.

Manufactured using high‑purity silica with fully double end‑capped bonding, this stationary phase provides:

• Reduced silanol interactions

• Improved peak symmetry for polar and basic analytes

• Stable operation with high aqueous mobile phases, including 100% water

The embedded amide functionality enhances interaction with polar compounds, preventing phase collapse seen with conventional C18 phases, while preserving reliable hydrophobic retention.

150 mm Length – Maximum Resolution for Method Development

• Higher resolving power than 50 mm and 100 mm columns

• Maximizes peak capacity for complex mixtures

• Ideal for closely related compounds and difficult separations

• Preferred for final method development before preparative scale‑up

• Longer run times compared to shorter formats

This configuration is selected when maximum separation performance is required before scaling methods to preparative or process chromatography.

4.6 mm ID – Standard Analytical Platform

• Compatible with standard HPLC systems

• Ideal for:

  • method development

  • routine analysis

  • preparative method transfer workflows

Typical Flow Rate Range

• ~0.8–1.5 mL/min

✅ Suitable for standard analytical systems without specialized flow requirements

10 µm Particle – Preparative Scouting & High‑Flow Capability

• Designed for higher flow rates and improved robustness

• Provides lower resistance to flow compared to smaller particle sizes

• Supports method transfer to preparative and process‑scale columns

✅ Ideal for scalable method development where durability and throughput are prioritized

Why Choose RP C18 PE™ (Polar Embedded)

Enhanced Polar Retention

• Retains polar compounds without phase collapse

• Stable under 100% aqueous mobile phase conditions

• Improves retention compared to standard C18 columns

Dual‑Mode Flexibility

• Operates in:

  • Reversed Phase (RP)

  • HILIC‑like modes under appropriate conditions

Ideal for Method Development & Scale‑Up

• Suitable for:

  • polar analytes poorly retained on conventional C18

  • scalable workflows from analytical to preparative chromatography

• Enables consistent and transferable method performance

USP Method Compatibility

• Suitable as a USP L1 alternate

• Ideal for methods requiring:

  • high aqueous mobile phases

  • robust and reproducible polar analyte retention

Typical Applications

• Analytical method development

• Preparative method scouting and optimization

• Polar and hydrophilic compound separations

• Pharmaceutical process development

• Long‑chain fatty acids

• Mixed polarity compound analysis

Cogent RP C18 PE™ Advantages

Polar Embedded Ligand

• Enhances interaction with polar analytes

• Maintains traditional C18 hydrophobic selectivity

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry and reproducibility

High Purity Silica

• Consistent chromatographic performance

• Reliable method transfer across systems

Important Usage Notes

• Designed for maximum‑resolution method development workflows

• Suitable for high aqueous mobile phases (including 100% water)

• Compatible with standard 4.6 mm analytical HPLC systems

• Ideal when scaling methods to preparative or process chromatography