HPLC Column, NP Diol, 5um, 2.1mm ID x 100mm Length, 100A. Cogent Brand. 1 EA.
Additional Information:
Cogent NP Diol™ HPLC Columns are designed for normal-phase and HILIC separations of polar and hydrophilic compounds. Manufactured using ultra-high purity silica bonded with a short hydrocarbon ligand containing a terminal diol functional group, this stationary phase provides reproducible retention, excellent stability, and broad solvent compatibility. The non-endcapped surface chemistry offers selectivity consistent with USP L20 classifications, making it an excellent choice for both established methods and new method development.
82560-10P-2 is packed with 5 µm NP Diol™ particles featuring a 100 Å pore size in a 2.1 mm ID x 100 mm format. The narrow internal diameter reduces solvent consumption and makes this column highly suitable for LC-MS applications while providing improved resolving power compared to shorter columns. NP Diol™ columns are frequently selected as alternatives to unmodified silica columns because they often provide greater robustness and compatibility with a wider range of solvents while maintaining similar retention characteristics for many applications.
The 2.1 mm ID x 100 mm format is ideal for HILIC separations, normal-phase chromatography, LC-MS methods, pharmaceutical analysis, and method development involving hydrophilic compounds. Typical flow rates are approximately 0.2-0.3 mL/min. Standard HPLC systems used with 2.1 mm ID columns must be capable of delivering stable and reproducible low flow rates for optimum chromatographic performance.
Key Benefits
NP Diol™ stationary phase
USP L20 equivalent chemistry
Ultra-high purity silica support
Terminal diol functional group
100 Å pore size
Suitable for HILIC applications
Suitable for normal-phase chromatography
Alternative to unmodified silica columns
Broad solvent compatibility
Excellent for LC-MS applications
Typical Applications
HILIC chromatography
Normal-phase HPLC
Polar compound analysis
Hydrophilic compound analysis
Pharmaceutical analysis
LC-MS methods
Method development
Quality control testing
Carbohydrate analysis
Metabolite analysis
Specifications
Product Type: HPLC Column
Stationary Phase: NP Diol™
Chromatography Mode: HILIC / Normal Phase
Functional Group: Diol
Particle Size: 5 µm
Pore Size: 100 Å
Column Dimensions: 2.1 mm ID x 100 mm
Recommended Flow Rate: 0.2-0.3 mL/min
Column Hardware: Stainless Steel
Brand: Cogent
Important Notes
Suitable for HILIC and normal-phase chromatography
Often used as an alternative to USP L20 columns
Provides retention of hydrophilic and polar compounds
More robust than many unmodified silica columns
Broad solvent compatibility for method flexibility
100 mm length provides increased resolution and peak capacity
Ideal for LC-MS methods and low-volume analyses
Useful for carbohydrates, metabolites, and other polar analytes
Suitable for both established methods and new method development
Standard HPLC systems must be capable of reliable low-flow operation at approximately 0.2-0.3 mL/min