Catalog Number - 68539-PG1

Cogent RP Phenyl Hexyl™ Guard Column Cartridges are designed to protect analytical HPLC columns from particulates, strongly retained compounds, and other contaminants that can reduce column performance and shorten column life. Packed with the same stationary phase as the analytical column, these guard cartridges help maintain chromatographic performance while reducing analytical column replacement costs and downtime.

68539-PG1 is packed with 5 µm RP Phenyl Hexyl™ stationary phase featuring a 100Å pore size. Manufactured using ultra-high purity silica bonded with a six-carbon linker and terminal Phenyl group, this stationary phase is fully double end-capped to minimize secondary interactions and provide highly reproducible chromatographic performance. The extended C6 linker increases the accessibility of the Phenyl group, enhancing π-π interactions and aromatic selectivity for compounds containing benzene ring structures.

These guard cartridges are specifically designed to protect 2.1 mm ID RP Phenyl Hexyl™ analytical HPLC columns from particulate contamination and strongly retained sample components. Routine guard cartridge replacement helps maintain column efficiency, reduce downtime, and extend analytical column service life. RP Phenyl Hexyl™ columns are often evaluated as an alternative to other Phenyl Hexyl stationary phases used in USP L11 methods, including Restek™ Phenyl Hexyl columns.

Key Benefits

• RP Phenyl Hexyl™ stationary phase

• USP L11 equivalent chemistry

• Ultra-high purity silica support

• Fully double end-capped

• Six-carbon linker with terminal Phenyl group

• 100Å pore size

• Suitable for reversed-phase chromatography

• Enhanced π-π interactions

• Protects analytical columns from contamination

• Extends analytical column life

Typical Applications

• Analytical HPLC

• LC-MS methods

• Column protection

• Aromatic compound separations

• Positional isomer separations

• Tocopherol analysis

• Flavonoid analysis

• Active pharmaceutical ingredient (API) analysis

• Natural product analysis

• Routine guard cartridge replacement

Specifications

• Product Type: Guard Column Cartridges

• Stationary Phase: RP Phenyl Hexyl™

• Chromatography Mode: Reversed Phase

• USP Classification: L11

• Particle Size: 5 µm

• Pore Size: 100Å

• Cartridge Dimensions: 2.1 mm ID x 10 mm

• Construction: Stainless Steel Cartridge

• Frit Material: Stainless Steel with PEEK Frit Caps

• Quantity: 5/PK

• Brand: Cogent

Guard Column Requirements

• A 83200-GH Guard Column Holder is required for use with these guard column cartridges.

• Designed for use with compatible Cogent RP Phenyl Hexyl™ 2.1 mm ID analytical HPLC columns.

Important Notes

• Suitable for reversed-phase chromatography

• USP L11 equivalent chemistry

• Fully double end-capped

• Enhanced π-π interactions improve aromatic selectivity

• Six-carbon linker increases distance from the silica surface

• Designed to protect RP Phenyl Hexyl™ analytical columns from particulates and strongly retained contaminants

• Helps extend analytical column life and maintain chromatographic performance

• Often evaluated as an alternative to Restek™ Phenyl Hexyl columns in USP L11 methods

• Requires a compatible Guard Column Holder

• Intended for routine replacement as part of preventive maintenance