Catalog Number - 68534-05P

Cogent RP Cyano™ HPLC Columns are designed for reversed-phase separations of polar and moderately hydrophobic compounds where alternative selectivity to C18 and C8 stationary phases is desired. Manufactured using ultra-high purity silica bonded with a three-carbon ligand and terminal Cyano functionality, this stationary phase provides unique chromatographic characteristics that make it an excellent choice for USP L10 methods and applications requiring reduced hydrophobic retention and rapid equilibration.

68534-05P is packed with 5 µm RP Cyano™ particles in a 4.6 mm ID x 50 mm format with a 100Å pore size. The 5 µm particle size performs well at conventional HPLC flow rates while maintaining lower operating backpressure than smaller particle columns. The short 50 mm length is ideal for rapid analyses, method development, and high-throughput laboratories seeking reduced run times and solvent consumption.

The RP Cyano™ stationary phase is not end capped and is frequently used for analysis of polar and neutral compounds in reversed-phase HPLC. Compared to non-modified silica columns, it provides shorter retention times and faster equilibration between runs. Typical operating flow rates for a 4.6 mm ID column are approximately 1.0–2.0 mL/min depending on mobile phase composition, method requirements, and system capabilities.

Key Benefits

• RP Cyano™ stationary phase

• USP L10 equivalent chemistry

• Ultra-high purity silica support

• Three-carbon linker with terminal Cyano group

• Not end capped

• 100Å pore size

• Suitable for reversed-phase chromatography

• Alternative selectivity to C18 and C8 phases

• Faster equilibration between runs

• Ideal for rapid analytical methods

Typical Applications

• Reversed-phase HPLC

• USP L10 methods

• Polar compound separations

• Neutral compound separations

• Method development

• Routine quality control testing

• Pharmaceutical analysis

• Chemical analysis

• High-throughput laboratories

• Alternative selectivity screening

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP Cyano™

• Chromatography Mode: Reversed Phase

• USP Classification: L10

• Particle Size: 5 µm

• Pore Size: 100Å

• Column Dimensions: 4.6 mm ID x 50 mm

• Recommended Flow Rate: 1.0–2.0 mL/min

• Column Hardware: Stainless Steel

• Brand: Cogent

Important Notes

• Suitable for reversed-phase chromatography

• USP L10 equivalent chemistry

• Not end capped

• Provides alternative selectivity compared to C18 and C8 columns

• Often used for polar and neutral compounds

• Faster equilibration than non-modified silica columns

• Short 50 mm length helps reduce run times and solvent consumption

• Packed and shipped in reversed-phase solvents

• Normal-phase versions are also available