Catalog Number - 68518-PG2

The 68518‑PG2 Cogent RP C18 Guard Column Cartridges are designed to extend the life of analytical HPLC columns, providing reliable protection against particulates, strongly retained analytes, and sample matrix contamination in routine and high‑throughput workflows.

Packed with 5 µm Cogent RP C18™ stationary phase and manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, these cartridges are fully double end‑capped to deliver:

• Reduced silanol interactions

• Improved peak symmetry for polar and basic analytes

• Consistent chromatographic protection across routine analyses

Each cartridge is constructed in a stainless steel housing with stainless steel frits, secured with PEEK frit caps for durability and reliable sealing in analytical systems.

Designed for Analytical Columns (3.0–4.6 mm ID)

• Compatible with:

  • 3.0 mm ID solvent‑saving columns

  • 4.0 mm ID analytical columns

  • 4.6 mm ID standard HPLC columns

✅ Maintains method selectivity and chromatographic consistency

Purpose of Guard Columns

• Protect analytical columns from:

  • Particulate contamination

  • Strongly retained compounds

  • Sample matrix buildup and fouling

• Extend column lifetime

• Maintain retention time stability and peak shape

• Reduce downtime and replacement costs

5 µm Guard Media – Balanced Performance & Compatibility

• Matches standard analytical column particle size

• Provides balanced efficiency and durability

• Ideal for routine analysis and method development

✅ Delivers reliable protection without compromising chromatographic performance

Why Choose RP C18 Guard Cartridges (5 µm, 4.0 mm)

Matched Analytical Chemistry

• Same C18 stationary phase as analytical columns

• Maintains method integrity and reproducibility

• Prevents chromatographic variation

Extended Column Life

• Captures contaminants before reaching the analytical column

• Reduces irreversible fouling and column degradation

Workflow Efficiency

• Minimizes column replacement frequency

• Supports high‑throughput QC and analytical laboratories

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances reproducibility

High Purity Silica

• Consistent performance across injections

• Reliable guard‑to‑guard quality

Durable Construction

• Stainless steel cartridge body and frits

• PEEK sealing components

• Designed for routine analytical HPLC use

Important Usage Notes

• ⚠️ Must be used with a compatible guard column holder system

• Designed for analytical HPLC systems (3.0–4.6 mm ID columns)

• Replace regularly to maintain optimal chromatographic performance

• Essential for protecting high‑value analytical columns