Process HPLC Column, RP C18, 5um, 100A. 50mm ID x 250mm Length. Cogent Brand. 1 EA.
Additional Info:
The 68518‑P50‑250 Cogent RP C18 Process HPLC Column is engineered for maximum separation performance in industrial‑scale purification workflows, utilizing 5 µm particles and fully double end‑capped C18 bonding to deliver extreme loading capacity, consistent retention, and reliable chromatographic performance under manufacturing conditions.
Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:
Complete end‑capping to minimize silanol interactions
Improved peak symmetry for polar and basic analytes
Reproducible performance across large‑batch and continuous purification processes
This column is ideal as a USP L1 alternate and as a top‑tier solution for final purification and full industrial production workflows.
250 mm Length – Maximum Separation & Highest Purity
Highest resolving power in the 50 mm RP C18 (5 µm) process range
Maximizes peak capacity for highly complex mixtures
Ideal for closely related compounds and difficult separations
Provides extended retention for hydrophobic analytes
Best suited for final purification and highest‑purity isolation at process scale
This configuration is selected when shorter columns cannot achieve required resolution or purity in industrial workflows.
50 mm ID – Maximum Industrial‑Scale Loading
Provides extremely high sample loading capacity (beyond prep and production scale)
Designed for industrial purification, batch processing, and manufacturing workflows
Supports ultra‑high‑flow chromatography systems
Typical Flow Rate Range
~50–150 mL/min (system dependent)
Optimize based on process requirements and system capability
✅ Designed for process HPLC systems with ultra‑high flow rates and very large injection volumes
Flow Rate & System Considerations (50 mm ID, 5 µm)
Requires systems capable of:
Ultra‑high flow rates
Very large injection volumes
Compatible with:
Process chromatography systems
Industrial pumps and injection platforms
Large‑volume fraction collection or continuous processing systems
⚠️ Not suitable for analytical, semi‑prep, or standard preparative HPLC systems
Why Choose RP C18 (5 µm, Process Scale)
Maximum Resolution for Industrial Purification
Ideal for final purification of complex mixtures at manufacturing scale
Maximizes separation efficiency and product purity
Supports high‑purity compound isolation in process environments
Reliable Hydrophobic Retention
Strong reversed‑phase retention for hydrophobic and neutral compounds
Effective for lipids and long‑chain fatty acids
Provides greater retention than C8 phases
USP Method Compatibility
Suitable for USP L1 methods
Reliable for regulated industrial and pharmaceutical manufacturing
Supports method transfer across all HPLC scales
Cogent RP C18™ Advantages
Fully End‑Capped Surface
Minimizes secondary interactions
Improves peak symmetry
Stabilizes chromatographic performance at industrial scale
High Purity Silica
Consistent chromatographic results
Reduced variability across large‑batch production runs
Durable & Cost‑Efficient
Long column lifetime
Designed for continuous, high‑load process workflows
Reduces downtime and operational cost
Typical Applications
Process‑scale purification
Industrial manufacturing workflows
High‑purity compound isolation
Pharmaceutical production
Large‑scale process development
USP L1 reversed‑phase methods
Important Usage Notes
Designed for 50 mm ID process‑scale HPLC systems
Requires ultra‑high‑flow capability and very large sample loading volumes
Ideal for maximum‑resolution, high‑purity industrial workflows
Optimize for resolution vs throughput based on production goals
Made‑to‑Order & Pricing Information
This is a custom, made‑to‑order item.
Orders cannot be canceled once placed
Custom items are non‑returnable