Catalog Number - 68518-P21-150

The 68518‑P21‑150 Cogent RP C18 Preparative HPLC Column is engineered for high‑resolution purification and preparative method development, utilizing 5 µm particles and fully double end‑capped C18 bonding to deliver reliable retention, high loading capacity, and consistent chromatographic performance.

Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:

• Complete end‑capping to minimize silanol interactions

• Improved peak symmetry for polar and basic analytes

• Consistent and reproducible purification results

This column is ideal as a USP L1 alternate and as a high‑performance platform for preparative purification workflows.

150 mm Length – Maximum Resolution for Preparative Purification

• Higher resolving power than 50 mm and 100 mm formats

• Maximizes peak capacity for complex separations

• Ideal for closely related compounds and difficult mixtures

• Preferred for final purification and high‑purity isolation

• Longer run times compared to shorter columns

This configuration is selected when maximum separation performance is required before final scale‑up or production workflows.

21.2 mm ID – High‑Capacity Preparative Scale

• Provides very high sample loading capacity

• Designed for large‑scale purification and batch processing

• Supports high‑flow preparative chromatography workflows

Typical Flow Rate Range

• ~10–30 mL/min (system dependent)

• Optimize based on instrument capability and purification requirements

✅ Designed for preparative HPLC systems capable of high flow rates and large injection volumes

Flow Rate & System Considerations (21.2 mm ID, 5 µm)

• Requires systems capable of:

  • High flow rates

  • Large injection volumes

• Compatible with:

  • Preparative pumps

  • High‑volume injection systems

  • Fraction collection systems

⚠️ Not intended for analytical or semi‑prep HPLC systems

Why Choose RP C18 (5 µm, Preparative Scale)

Maximum Resolution for Purification

• Ideal for final purification of complex mixtures

• Maximizes separation efficiency and product purity

• Supports high‑purity isolation workflows

Reliable Hydrophobic Retention

• Strong reversed‑phase retention for hydrophobic and neutral compounds

• Excellent for long‑chain fatty acids

• Provides greater retention than C8 phases

USP Method Compatibility

• Suitable for USP L1 methods

• Reliable for regulated and validated workflows

• Supports method transfer across systems and scales

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances performance for challenging analytes

High Purity Silica

• Consistent chromatographic performance

• Reduced variability between batches

Durable & Cost‑Efficient

• Long column lifetime

• Designed for high‑load purification cycles

• Reduced system maintenance requirements

Typical Applications

• Preparative purification

• High‑purity compound isolation

• Complex mixture separations

• Pharmaceutical and QC workflows

• Pilot‑scale and production processes

• USP L1 reversed‑phase methods

Important Usage Notes

• Designed for preparative HPLC systems (21.2 mm ID)

• Requires high‑flow capability and large sample loading capacity

• Ideal for maximum‑resolution purification workflows

• Optimize conditions for resolution vs throughput balance

Made‑to‑Order & Pricing Information

This is a custom, made‑to‑order item.

• Orders cannot be canceled once placed

• Custom items are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification:

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.