Catalog Number - 68512-PG1

Cogent RP C12™ Guard Column Cartridges are designed to protect analytical HPLC columns from particulates, strongly retained compounds, and sample contaminants that can reduce column performance and shorten column life. Packed with the same RP C12™ stationary phase used in Cogent analytical columns, these guard cartridges help maintain chromatographic consistency while extending the service life of your analytical column. The stationary phase is manufactured using a rigid adamantane-shaped carbon silane ligand bonded to ultra-high purity silica and fully double end capped to provide reproducible reversed-phase performance and rapid equilibration.

68512-PG1 is a guard column cartridge packed with 5 µm RP C12™ particles featuring a 100 Å pore size in a 2.1 mm ID x 10 mm format. Designed specifically to protect 2.1 mm ID RP C12 analytical columns, these cartridges capture particulates and contaminants before they reach the analytical column bed. The unique RP C12™ chemistry provides selectivity between traditional C8 and C18 phases while maintaining compatibility with highly aqueous mobile phases, including 100% water. Constructed using stainless steel tubes with stainless steel frits pressed into durable PEEK frit caps, they provide reliable performance in demanding HPLC and LC-MS applications.

Routine replacement of guard column cartridges helps maintain column efficiency, preserve peak shape, reduce downtime, and lower overall operating costs by protecting more expensive analytical columns. These cartridges are particularly valuable for pharmaceutical analysis, LC-MS methods, method development, quality control testing, and complex sample matrices.

Key Benefits

• RP C12™ stationary phase

• Adamantane-shaped bonded ligand

• Fully double end capped

• Ultra-high purity silica support

• 100 Å pore size

• Protects analytical HPLC columns

• Extends column lifetime

• Maintains chromatographic performance

• Compatible with 100% aqueous mobile phases

• Supplied in convenient 5-pack format

Typical Applications

• Reversed-phase HPLC

• LC-MS methods

• Pharmaceutical analysis

• Quality control testing

• Method development

• High-throughput screening (HTS)

• Complex mixture separations

• Routine analytical HPLC

• Research and development

• Column protection

Specifications

• Product Type: Guard Column Cartridge

• Stationary Phase: RP C12™

• Chromatography Mode: Reversed Phase

• Bonded Phase: Adamantane-Shaped C12 Ligand

• Endcapping: Fully Double End Capped

• Particle Size: 5 µm

• Pore Size: 100 Å

• Cartridge Dimensions: 2.1 mm ID x 10 mm

• Construction: Stainless Steel Tube, Stainless Steel Frits, PEEK Frit Caps

• Quantity: 5/PK

• Brand: Cogent

Important Notes

• Designed to protect 2.1 mm ID RP C12 analytical columns from particulates and contaminants

• Helps extend analytical column service life and maintain chromatographic performance

• Provides a selectivity profile between traditional C8 and C18 phases

• Compatible with highly aqueous and 100% water mobile phases

• Suitable for HPLC and LC-MS applications

• Particularly useful with complex or highly contaminated sample matrices

• Routine replacement helps reduce analytical column replacement costs

• A Cogent Guard Column Holder (83200-GH) is required for use with these guard column cartridges

• Compatible with Cogent 2.1 mm ID RP C12 analytical columns

• Supplied as a package of five replacement cartridges