HPLC Column, RP C18, 3um, 4.6mm ID x 100mm Length, 100A. Cogent Brand. 1 EA.
Additional Info:
The 68318‑10P Cogent RP C18 HPLC Column is a trusted, high‑value reversed‑phase column featuring 3 µm particles and fully double end‑capped C18 bonding, providing improved efficiency, strong retention, and consistent analytical performance.
Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase:
Uses complete end‑capping to minimize silanol activity
Improves peak shape for polar and basic analytes
Provides reliable and reproducible chromatography
This column is widely used as a primary analytical column, as well as an alternate for USP L1 classified methods requiring 3 µm stationary phases.
100 mm Length – Increased Resolution
Higher resolving power compared to 50 mm columns
Improved separation of closely related compounds
Ideal when short columns do not provide sufficient resolution
Balanced performance between run time and separation quality
This format is commonly selected when faster methods are needed but 50 mm columns cannot achieve required resolution.
4.6 mm ID – Standard Analytical Performance
Industry‑standard HPLC column dimension
Compatible with all conventional HPLC systems
Typical flow rate range: ~0.8–1.5 mL/min
Optimal starting range: ~1.0–1.2 mL/min
Provides:
Strong detector response
Excellent reproducibility
Easy method transfer between systems
Why Choose RP C18 (3 µm)
Balanced Efficiency & Pressure
More efficient than 5 µm columns
Lower backpressure than sub‑2 µm UHPLC columns
Ideal balance between performance and system compatibility
Reliable Hydrophobic Retention
Strong reversed‑phase retention for hydrophobic and neutral compounds
Excellent for long‑chain fatty acids and similar analytes
Method Development Versatility
Ideal for new method development
Compatible with a wide range of analytical methods
Suitable for USP L1 method substitution
Cogent RP C18™ Advantages
Fully End‑Capped Surface
Minimizes secondary interactions
Improves peak symmetry
Better performance for basic compounds
High Purity Silica
Consistent, reproducible chromatography
Reduced variability between runs and columns
Cost‑Efficient Operation
Lower pressure requirements vs UHPLC columns
Reduced solvent usage vs longer column formats
Lower cost per analysis
Typical Applications
Pharmaceutical and QC analysis
Hydrophobic and neutral compound separations
Long‑chain fatty acids
Method development and validation
Routine analytical HPLC workflows
USP L1 reversed‑phase methods
Important Usage Notes
Compatible with standard HPLC systems
Monitor system pressure when using viscous solvents or extended methods
Ideal for applications requiring improved resolution over short columns
A strong choice when balancing speed, performance, and system compatibility