HPLC Column, RP C8 Octyl, Wide Pore, 3um, 2.1mm ID x 150mm Length, 300A. Cogent Brand. 1 EA.
Additional Information:
Cogent RP C8 Octyl™ Wide Pore is a reversed-phase HPLC stationary phase specifically designed for the separation of large hydrophobic and neutral molecules. Manufactured using a traditional octyl (C8) bonded phase on ultra-high purity silica and fully double end capped, this 300 Å wide pore chemistry provides enhanced accessibility for larger analytes compared to standard 100 Å pore columns. As a USP L7 equivalent phase, it is particularly useful for proteins, peptides, long-chain fatty acids, and other compounds that benefit from improved pore accessibility and mass transfer.
68308-15P-2-3M is an HPLC column packed with 3 µm RP C8 Octyl™ Wide Pore particles featuring a 300 Å pore size in a 2.1 mm ID x 150 mm format. This narrow-bore configuration combines maximum chromatographic resolution with reduced solvent consumption and excellent compatibility with LC-MS instrumentation. The 150 mm length provides exceptional peak capacity and resolving power for complex separations, while the wide pore structure allows larger molecules to efficiently access the bonded phase for improved chromatographic performance. Typical operating flow rates are approximately 0.2–0.3 mL/min. Because of the low flow rates required by 2.1 mm ID columns, standard HPLC systems must be capable of precise and reproducible low-flow operation.
This column is particularly useful for large hydrophobic or neutral compounds analyzed by reversed-phase HPLC and LC-MS. The C8 chemistry offers balanced hydrophobic retention while the 300 Å pore structure improves performance for larger analytes including proteins, peptides, and long-chain fatty acids. This format is often selected for LC-MS methods when maximum resolution and peak capacity are required.
Key Benefits
RP C8 Octyl™ Wide Pore stationary phase
USP L7 equivalent chemistry
Fully double end capped
Traditional octyl (C8) bonded phase
Ultra-high purity silica support
300 Å wide pore design
Optimized for large molecules
3 µm particle technology
Maximum peak capacity
Excellent for LC-MS applications
Typical Applications
USP L7 methods
LC-MS methods
Protein analysis
Peptide analysis
Long-chain fatty acid analysis
Large molecule separations
Biopharmaceutical analysis
Hydrophobic compound analysis
Method development
Reversed-phase HPLC
Specifications
Product Type: HPLC Column
Stationary Phase: RP C8 Octyl™ Wide Pore
USP Classification: L7
Chromatography Mode: Reversed Phase
Bonded Phase: Octyl (C8)
Endcapping: Fully Double End Capped
Particle Size: 3 µm
Pore Size: 300 Å
Column Dimensions: 2.1 mm ID x 150 mm
Length: 150 mm
Typical Flow Rate: 0.2–0.3 mL/min
Brand: Cogent
Important Notes
Designed for large hydrophobic and neutral molecules
300 Å wide pores improve access to the bonded phase for larger analytes
Suitable for conventional HPLC and LC-MS systems
The 2.1 mm ID format is commonly used for LC-MS applications
Standard HPLC systems must be capable of precise and reproducible operation at approximately 0.2–0.3 mL/min
Detector flow cells should be optimized for low-volume, narrow-bore chromatography
The 150 mm length maximizes resolution and peak capacity for complex separations
Particularly useful for proteins, peptides, and long-chain fatty acids
Provides balanced hydrophobic retention for large molecule separations
Commonly used as an alternative for USP L7 methods involving larger analytes