UHPLC Column, RP C18, 1.8um, 100A. 2.1mm ID x 100mm Length. Cogent Brand. 1 EA.
Additional Info:
The 68118‑10P‑2 Cogent RP C18 UHPLC Column is a high‑efficiency reversed‑phase column featuring 1.8 µm particles and fully double end‑capped C18 bonding, delivering maximum resolution, peak capacity, and method reliability.
Manufactured with high‑purity silica and traditional octadecylsilane (C18) bonding, this column:
Minimizes silanol activity through complete end‑capping
Improves peak shape for polar and basic analytes
Provides highly reproducible and robust chromatographic performance
This column is widely used as a primary method development and LC‑MS column due to its versatility and performance.
100 mm Length – Increased Resolution for LC‑MS
Higher resolving power compared to 50 mm columns
Improved peak capacity and separation of closely related analytes
Ideal for LC‑MS workflows requiring enhanced resolution
Balanced performance between speed and separation quality
This is one of the most popular UHPLC column formats, especially for analytical workflows requiring greater resolution without excessive run time.
Flow Rate & System Requirements (2.1 mm ID, 1.8 µm)
⚠️ Requires UHPLC system capability due to high backpressure
Typical flow rate range: ~0.2–0.5 mL/min
Optimal starting range: ~0.2–0.35 mL/min for resolution
Requires:
UHPLC system capable of high‑pressure operation
Low‑volume detector flow cell
Accurate low‑flow pumping
✅ Sample preparation requirement: filter samples using a 0.2 µm syringe filter before injection to prevent clogging.
⚠️ Standard HPLC systems must be capable of stable low‑flow operation and may not support required pressures.
Why Choose RP C18 for UHPLC
High Efficiency & Resolution
1.8 µm particles provide maximum plate count
Greater peak capacity than 3 µm columns
Maintains resolution even with shorter run times
Reliable Hydrophobic Retention
Ideal for hydrophobic and neutral compounds
Strong and reproducible reversed‑phase behavior
Versatile Method Development
Widely used across analytical laboratories
Excellent first‑choice column for new methods
Easily scalable to longer column lengths or different IDs
Cogent RP C18™ Advantages
Fully End‑Capped Surface
Minimizes secondary interactions
Improves peak symmetry
Better performance for basic compounds
High Purity Silica
Consistent performance across batches
Improved reproducibility
Cost‑Efficient UHPLC Operation
Reduced solvent consumption with 2.1 mm ID
Increased throughput
Lower cost per analysis
Typical Applications
LC‑MS analytical workflows
Pharmaceutical and QA/QC analysis
Hydrophobic and neutral compound separations
Method development and optimization
High‑resolution UHPLC applications
Important Usage Notes
Requires UHPLC system capable of high pressure
Use 0.2 µm filtration to protect column integrity
Ideal for high‑efficiency, high‑resolution workflows
One of the most common formats for LC‑MS applications