Catalog Number - 68118-10P

The 68118‑10P Cogent RP C18 UHPLC Column is a high‑efficiency reversed‑phase column featuring 1.8 µm particles and fully double end‑capped C18 bonding, delivering enhanced resolution, strong retention, and reliable chromatographic performance.

Manufactured with high‑purity silica and traditional octadecylsilane bonding, this column offers:

• Complete end‑capping to minimize silanol activity

• Improved peak shape for polar and basic analytes

• High reproducibility for routine and advanced analytical work

This column is a trusted option for method development and routine UHPLC applications, offering consistent, predictable results.

100 mm Length – Increased Resolution

• Higher resolving power than 50 mm columns

• Improved separation of closely related compounds

• Ideal when 50 mm columns do not provide sufficient resolution

• Balanced performance between speed and separation quality

This configuration is commonly used when greater resolution is required without the longer run times of 150 mm columns.

Flow Rate & System Requirements (4.6 mm ID, 1.8 µm)

⚠️ Requires UHPLC system capability due to increased backpressure

• Typical flow rate range: ~1.0–2.0 mL/min

• Optimal starting range: ~1.2–1.5 mL/min

• Requires:

  • UHPLC system capable of high‑pressure operation

  • Standard flow detector compatible with 4.6 mm ID

  • Stable high‑flow pumping capability

✅ Sample preparation requirement: filter samples using a 0.2 µm syringe filter prior to injection to protect the column.

Why Choose RP C18 for UHPLC

High Efficiency & Resolution

• 1.8 µm particles provide maximum plate count and peak capacity

• Significantly better performance than 3 µm+ columns

• Enables resolution improvements without drastically increasing run time

Reliable Hydrophobic Retention

• Strong, predictable reversed‑phase behavior

• Ideal for hydrophobic and neutral compounds

Versatile Method Development Platform

• Widely applicable across industries

• Excellent starting point for new method development

• Easily scalable across column dimensions

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Better performance for basic analytes

High Purity Silica

• Consistent column‑to‑column performance

• Improved analytical reproducibility

Cost‑Efficient Operation

• Reduced solvent usage compared to longer columns

• Increased throughput

• Lower cost per analysis

Typical Applications

• Pharmaceutical and QC analysis

• Hydrophobic and neutral compound separations

• Method development and optimization

• Routine reversed‑phase workflows

• High‑efficiency UHPLC analysis

Important Usage Notes

• Requires UHPLC instrumentation capable of high pressure

• Use 0.2 µm filtration to prevent column fouling

• Ideal for applications requiring more resolution than short columns can provide

• Suitable for standard‑flow UHPLC systems