UHPLC Column, RP C18, 1.8um, 100A. 2.1mm ID x 50mm Length. Cogent Brand. 1 EA.
Additional Info:
The 68118‑05P‑2 Cogent RP C18 UHPLC Column is a high‑efficiency reversed‑phase column featuring 1.8 µm particles and fully end‑capped C18 bonding, delivering maximum efficiency, high resolution, and reliable retention for hydrophobic analytes.
This column is manufactured using high‑purity silica with traditional C18 (octadecylsilane) bonding, combined with double end‑capping, which:
Minimizes residual silanol interactions
Improves peak shape for polar and basic compounds
Enhances reproducibility and method robustness
The result is a dependable, “first‑choice” C18 column for both routine analysis and method development.
50 mm Length – Speed & UHPLC Throughput
Designed for short run times and rapid analysis
Lower backpressure compared to longer columns
Ideal for high‑throughput workflows and screening
Suitable for fast method development and LC‑MS applications
Flow Rate & System Requirements (2.1 mm ID, 1.8 µm)
Requires UHPLC system capability
Typical flow rate range: ~0.2–0.5 mL/min
Optimal starting range: ~0.3–0.4 mL/min
Requires:
UHPLC system capable of high pressure operation
Low‑volume detector (optimized for 2.1 mm ID)
Precise low‑flow pumping
⚠️ Due to 1.8 µm particles, this column generates higher backpressure and may not be compatible with standard HPLC systems.
✅ Sample preparation requirement: filter samples with a 0.2 µm syringe filter prior to injection to prevent clogging.
Why Choose RP C18 for UHPLC
High Efficiency & Resolution
Sub‑2 µm particles provide maximum plate count
Improves resolution compared to 3 µm and larger particles
Maintains separation quality even with shorter run times
Reliable Hydrophobic Retention
Ideal for hydrophobic and neutral compounds
Strong and predictable reversed‑phase behavior
Method Development Versatility
Widely applicable across industries
Excellent starting point for new methods
Easy method transfer to longer column formats
Cogent RP C18™ Advantages
Fully End‑Capped Surface
Minimizes secondary interactions
Improves peak symmetry
Better performance for basic analytes
High Purity Silica
Consistent and reproducible separations
Reduced variability batch‑to‑batch
Cost‑Efficient Operation
Reduced solvent consumption with 2.1 mm ID
Increased throughput
Lower cost per analysis
Typical Applications
LC‑MS analytical workflows
Pharmaceutical and QC analysis
Hydrophobic and neutral compound separations
Method development and optimization
High‑throughput UHPLC analysis
Important Usage Notes
Requires UHPLC system capable of high pressure
Use 0.2 µm filtration to protect column integrity
Ideal for fast, high‑efficiency separations
Commonly used with LC‑MS systems