Catalog Number - 68018-PG2

The 68018‑PG2 Cogent RP C18 Guard Column Cartridges are designed to extend the life of analytical HPLC columns, providing effective protection against particulates, strongly retained contaminants, and sample matrix fouling.

Packed with 10 µm Cogent RP C18™ stationary phase, and manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, these cartridges are fully double end‑capped to provide:

• Reduced silanol activity

• Improved peak symmetry for polar and basic analytes

• Consistent chromatographic protection

Each cartridge is packed in a stainless steel body with stainless steel frits, secured with PEEK frit caps for durability and reliable sealing in analytical systems.

Designed for Analytical Columns (3.0–4.6 mm ID)

• Compatible with:

  • 3.0 mm ID solvent‑saving columns

  • 4.0 mm ID analytical columns

  • 4.6 mm ID standard HPLC columns

✅ Ensures consistent protection without altering chromatographic selectivity

Purpose of Guard Columns

• Protect analytical columns from:

  • Particulate contamination

  • Strongly retained compounds

  • Matrix buildup and fouling

• Extend column lifetime

• Maintain retention consistency and peak shape

• Reduce downtime and replacement costs

10 µm Guard Media – Analytical Compatibility & Durability

• Provides robust performance for routine analytical workflows

• Designed for high sample load analytical injections

• Ideal for method development and QC environments

✅ Supports longer service intervals compared to finer particle guards

Why Choose RP C18 Guard Cartridges (10 µm, Analytical Scale)

Matched Chemistry Protection

• Same C18 stationary phase chemistry as analytical columns

• Maintains method integrity and selectivity

• Prevents chromatographic drift

Extended Column Life

• Captures contaminants before reaching the analytical column

• Reduces column fouling and irreversible binding effects

Workflow Efficiency

• Minimizes system downtime and column replacement frequency

• Essential for high‑throughput laboratories and QC operations

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances reproducibility

High Purity Silica

• Reliable performance across runs

• Consistent guard‑to‑guard behavior

Durable Construction

• Stainless steel tube and frits

• PEEK‑based sealing components

• Designed for routine analytical use

Typical Applications

• Analytical HPLC method development

• Routine QC analysis

• Pharmaceutical and environmental testing

• Sample‑intensive workflows

• USP L1 reversed‑phase methods

Important Usage Notes

• Must be used with a compatible guard column holder system

• Replace regularly to maintain optimal column performance

• Ideal for protecting high‑value analytical columns