Process HPLC Column, RP C18, Wide Pore, 10um, 300A. 50mm ID x 50mm Length. Cogent Brand. 1 EA.
Additional Info:
The 68018‑P50‑50‑3M Cogent RP C18 Wide Pore Process HPLC Column is designed for industrial‑scale biomolecule purification and process chromatography development, combining 10 µm particles with a 300 Å wide‑pore structure to deliver maximum durability, extremely high loading capacity, and efficient analyte accessibility.
Manufactured using high‑purity 300 Å silica with traditional octadecylsilane (C18) bonding and fully double end‑capped, this stationary phase provides:
Reduced silanol interactions
Improved peak shape for proteins, peptides, and large polar analytes
Consistent and reproducible performance in high‑throughput process workflows
The 300 Å pore structure enables large biomolecules to fully access the stationary phase, minimizing restricted diffusion and improving recovery compared to 100 Å media.
This column is ideal as a USP L1 alternate for large‑molecule methods and as a fast‑throughput platform for process‑scale biomolecule purification workflows.
50 mm Length – Fast Biomolecule Scouting & Process Screening
Designed for rapid separations and short cycle times
Ideal for early‑stage process method development
Minimizes solvent consumption in large‑scale screening
Enables high‑throughput purification and process optimization
50 mm ID – Maximum Industrial‑Scale Loading
Provides extremely high sample loading capacity (top tier across entire column system)
Designed for industrial purification, manufacturing workflows, and continuous processing
Supports ultra‑high‑flow chromatography systems
Typical Flow Rate Range
~50–150 mL/min (system dependent)
Optimize based on process requirements and system capability
✅ Designed for process HPLC systems capable of ultra‑high flow rates and very large injection volumes
Flow Rate & System Considerations (50 mm ID, 10 µm, 300 Å)
Requires systems capable of:
Ultra‑high flow rates
Very large injection volumes
Compatible with:
Process chromatography systems
Industrial pumps and injection platforms
Large‑volume fraction collection or continuous processing systems
⚠️ Not suitable for analytical, semi‑prep, or standard preparative HPLC systems
Why Choose Wide Pore (300 Å) C18 (10 µm, Process Scale)
Designed for Biomolecules
Enables purification of:
Proteins
Peptides
Large hydrophobic compounds
Eliminates mass transfer limitations of smaller pore structures
High‑Throughput Process Purification
Ideal for industrial‑scale workflows requiring speed and robustness
Maximizes throughput and sample loading capacity
Supports efficient purification in manufacturing environments
Scalable Workflow Integration
Predictable selectivity across analytical → semi‑prep → prep → production → process
Supports seamless method transfer and industrial scale‑up
Cogent RP C18™ Advantages
Fully End‑Capped Surface
Minimizes secondary interactions
Improves peak symmetry
Enhances stability for biomolecule separations at scale
High Purity Silica
Consistent chromatographic performance
Reduced variability across large‑scale and continuous runs
Durable & Cost‑Efficient
Long column lifetime
Designed for high‑load industrial workflows
Reduces maintenance and operational costs
Typical Applications
Industrial‑scale biomolecule purification
Protein and peptide separations
Process method development and screening
Pharmaceutical manufacturing
Continuous processing systems
USP L1 wide‑pore reversed‑phase methods
Important Usage Notes
Designed for 300 Å wide‑pore biomolecule applications
Requires process‑scale HPLC system capability (50 mm ID)
Ideal for fast screening prior to longer column or full production workflows
Optimize for throughput vs resolution depending on process goals
Made‑to‑Order & Pricing Information
This is a custom, made‑to‑order item.
Orders cannot be canceled once placed
Custom items are non‑returnable