Process HPLC Column, RP C18, 10um, 100A. 50mm ID x 250mm Length. Cogent Brand. 1 EA.
Additional Info:
The 68018‑P50‑250 Cogent RP C18 Process HPLC Column is engineered for maximum separation performance in industrial‑scale purification workflows, utilizing 10 µm particles and fully double end‑capped C18 bonding to deliver exceptional durability, extremely high loading capacity, and reliable chromatographic performance under continuous and high‑throughput conditions.
Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:
Complete end‑capping to minimize silanol interactions
Improved peak symmetry for polar and basic analytes
Consistent and reproducible performance across large‑batch and continuous processing operations
This column serves as a USP L1 alternate and represents a top‑tier solution for final purification at industrial manufacturing scale.
250 mm Length – Maximum Separation & Highest Purity
Highest resolving power in the 50 mm RP C18 (10 µm) process range
Maximizes peak capacity for highly complex mixtures
Ideal for closely related compounds and challenging separations
Provides extended retention for hydrophobic analytes
Best suited for final purification and highest‑purity isolation in process environments
This configuration is selected when no shorter column can meet resolution or purity requirements at full production scale.
50 mm ID – Maximum Industrial‑Scale Loading
Provides extremely high sample loading capacity (highest level in full column ecosystem)
Designed for industrial purification, batch manufacturing, and continuous process workflows
Supports ultra‑high‑flow chromatography systems
Typical Flow Rate Range
~50–150 mL/min (system dependent)
Optimize based on process demands and system capability
✅ Designed for process HPLC systems capable of ultra‑high flow rates and very large injection volumes
Flow Rate & System Considerations (50 mm ID, 10 µm)
Requires systems capable of:
Ultra‑high flow rates
Very large injection volumes
Compatible with:
Industrial‑scale chromatography systems
High‑capacity pumps and injection platforms
Large‑volume fraction collection and continuous processing systems
⚠️ Not suitable for analytical, semi‑prep, or standard preparative HPLC systems
Why Choose RP C18 (10 µm, Process Scale)
Maximum Resolution for Industrial Purification
Ideal for final purification of complex mixtures at manufacturing scale
Maximizes separation efficiency and product purity
Supports high‑purity compound isolation and production workflows
Reliable Hydrophobic Retention
Strong reversed‑phase retention for hydrophobic and neutral compounds
Effective for lipids and long‑chain fatty acids
Provides greater retention than C8 phases
Method Development to Full Manufacturing
Enables efficient transition from development to industrial process scale
Maintains consistent performance across analytical → semi‑prep → prep → production → process workflows
Cogent RP C18™ Advantages
Fully End‑Capped Surface
Minimizes secondary interactions
Improves peak symmetry
Enhances robustness in high‑load industrial environments
High Purity Silica
Consistent chromatographic performance
Reduced variability across large production batches and continuous runs
Durable & Cost‑Efficient
Long column lifetime
Designed for continuous, high‑throughput process workflows
Reduces downtime and overall operational cost
Typical Applications
Industrial‑scale purification
High‑purity compound isolation
Complex mixture separations
Pharmaceutical manufacturing and QC
Process development and industrial scale‑up
USP L1 reversed‑phase methods
Important Usage Notes
Designed for 50 mm ID process‑scale HPLC systems
Requires ultra‑high‑flow capability and very large sample loading volumes
Ideal for maximum‑resolution, high‑purity industrial workflows
Optimize for resolution vs throughput based on production objectives
Made‑to‑Order & Pricing Information
This is a custom, made‑to‑order item.
Orders cannot be canceled once placed
Custom items are non‑returnable