Process HPLC Column, RP C18, 10um, 100A. 50mm ID x 100mm Length. Cogent Brand. 1 EA.
Additional Info:
The 68018‑P50‑100 Cogent RP C18 Process HPLC Column is engineered for industrial‑scale purification and process chromatography development, utilizing 10 µm particles and fully double end‑capped C18 bonding to deliver maximum robustness, extremely high loading capacity, and durable chromatographic performance in manufacturing environments.
Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:
Complete end‑capping to minimize silanol interactions
Improved peak symmetry for polar and basic analytes
Consistent and reproducible performance in large‑volume production workflows
This column is ideal as a USP L1 alternate and as a refinement platform for scaling purification processes into full industrial operation.
100 mm Length – Increased Resolution for Process Development
Higher resolving power than 50 mm process scouting columns
Improves separation of closely related compounds
Increases peak capacity for large‑scale purification workflows
Ideal for refining methods prior to longer columns or full production runs
This configuration is selected when greater resolution is required beyond initial process‑scale screening.
50 mm ID – Maximum Industrial‑Scale Loading
Provides extremely high sample loading capacity (top tier of entire column hierarchy)
Designed for industrial purification, manufacturing workflows, and continuous processing
Supports ultra‑high‑flow chromatography systems
Typical Flow Rate Range
~50–150 mL/min (system dependent)
Optimize based on process requirements and system capability
✅ Designed for process HPLC systems capable of ultra‑high flow rates and very large injection volumes
Flow Rate & System Considerations (50 mm ID, 10 µm)
Requires systems capable of:
Ultra‑high flow rates
Very large injection volumes
Compatible with:
Process chromatography systems
Industrial pumps and injection platforms
Large‑volume fraction collection or continuous processing systems
⚠️ Not suitable for analytical, semi‑prep, or standard preparative HPLC systems
Why Choose RP C18 (10 µm, Process Scale)
Method Development to Industrial Production
Ideal for developing and refining purification workflows at process scale
Enables efficient transition to longer columns and full manufacturing systems
Supports consistent analytical → semi‑prep → prep → production → process scaling
Reliable Hydrophobic Retention
Strong reversed‑phase retention for hydrophobic and neutral compounds
Effective for lipids and long‑chain fatty acids
Provides greater retention than C8 phases
USP Method Compatibility
Suitable for USP L1 methods
Reliable for validated industrial and pharmaceutical environments
Supports method transfer across all chromatography scales
Cogent RP C18™ Advantages
Fully End‑Capped Surface
Minimizes secondary interactions
Improves peak symmetry
Enhances robustness under high‑load industrial conditions
High Purity Silica
Consistent chromatographic performance
Reduced variability across large‑scale production and continuous runs
Durable & Cost‑Efficient
Long column lifetime
Designed for high‑load and continuous process workflows
Reduces downtime and operational costs
Typical Applications
Industrial‑scale purification
Process chromatography development
Hydrophobic and neutral compound separations
Pharmaceutical manufacturing
Continuous processing systems
USP L1 reversed‑phase methods
Important Usage Notes
Designed for 50 mm ID process‑scale HPLC systems
Requires ultra‑high‑flow capability and very large sample loading volumes
Ideal for method refinement prior to full production or continuous processing
Choose when robustness, throughput, and loading capacity are prioritized
Made‑to‑Order & Pricing Information
This is a custom, made‑to‑order item.
Orders cannot be canceled once placed
Custom items are non‑returnable