Catalog Number - 68018-P30-PG1

The 68018‑P30‑PG1 Cogent RP C18 Prep Guard Column Cartridge is designed to protect high‑value preparative HPLC columns operating at production scale, ensuring extended column life and consistent chromatographic performance.

Packed with 10 µm Cogent RP C18™ stationary phase and manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this cartridge is fully double end‑capped to provide:

• Reduced silanol interactions

• Improved peak shape for polar and basic analytes

• Reliable and reproducible chromatographic protection

Constructed in a stainless steel housing with stainless steel frits, this cartridge is built for durability in high‑flow, high‑load environments.

Purpose of Guard Columns

• Protect preparative columns from:

  • Particulate contamination

  • Strongly retained compounds

  • Sample matrix buildup and fouling

• Extend column lifetime

• Maintain consistent retention and peak shape

• Reduce downtime and replacement costs

10 µm Guard Media – Preparative Compatibility

• Matches 10 µm preparative column packing

• Supports very high sample loading workflows

• Ideal for preparative and production‑scale chromatography

✅ Maintains consistent selectivity across scale‑up workflows

\30 mm ID – Production‑Scale Systems

• Designed for 30 mm ID preparative HPLC columns

• Supports very high flow rates and large injection volumes

• Ideal for pilot‑scale and full production purification workflows

⚠️ Requires a 30 mm ID prep guard column holder system

Why Choose RP C18 Guard Cartridges (10 µm, 30 mm Prep Scale)

Matched Stationary Phase Protection

• Same C18 chemistry as the preparative column

• Maintains method selectivity and chromatographic behavior

• Prevents method drift during scale‑up

High‑Load Protection

• Designed to handle large injection volumes and high sample loads

• Protects columns in production‑level purification workflows

Preparative Workflow Alignment

• Ideal for semi‑prep → prep → production scale transitions

• Supports consistent chromatography across workflows

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Stabilizes chromatographic performance

High Purity Silica

• Reliable cartridge‑to‑cartridge consistency

• Reproducible protection across extended runs

Durable Construction

• Stainless steel housing and frits

• Designed for high‑flow production systems

Typical Applications

• Production‑scale HPLC purification

• Preparative column protection

• High‑load separations

• Pharmaceutical manufacturing and QC

• Hydrophobic and neutral compound purification

• USP L1 reversed‑phase methods

Important Usage Notes

• Designed for preparative HPLC systems (30 mm ID)

• Must be used with a compatible prep guard column holder

• Replace regularly to maintain optimal column performance

• Critical for protecting high‑value production columns

Made‑to‑Order & Pricing Information

This is a custom, made‑to‑order item.

• Orders cannot be canceled once placed

• Custom items are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification:

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.