Catalog Number - 68018-P30-50

The 68018‑P30‑50 Cogent RP C18 Preparative HPLC Column is designed for high‑throughput preparative method development and production‑scale purification, utilizing 10 µm particles and fully double end‑capped C18 bonding to deliver robust performance, very high loading capacity, and durable chromatographic operation.

Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:

• Complete end‑capping to minimize silanol interactions

• Improved peak symmetry for polar and basic analytes

• Consistent and reproducible purification results

This column is ideal as a USP L1 alternate and as a starting platform for preparative and production‑scale workflows.

50 mm Length – Fast Production‑Scale Scouting

• Designed for rapid separations and short cycle times

• Ideal for early‑stage production method development

• Minimizes solvent usage during high‑volume screening

• Enables high‑throughput purification workflows

30 mm ID – Maximum Production‑Scale Loading

• Provides extremely high sample loading capacity

• Designed for large‑scale purification and manufacturing workflows

• Supports very high‑flow preparative chromatography systems

Typical Flow Rate Range

• ~20–60 mL/min (system dependent)

• Optimize based on instrument capability and production requirements

✅ Designed for production‑scale HPLC systems with high flow and large injection volumes

Flow Rate & System Considerations (30 mm ID, 10 µm)

• Requires systems capable of:

  • Very high flow rates

  • Large injection volumes

• Compatible with:

  • Production preparative pumps

  • Large‑volume injection systems

  • High‑capacity fraction collection systems

⚠️ Not intended for analytical or semi‑prep HPLC systems

Why Choose RP C18 (10 µm, Production Scale)

Ideal for Preparative Scouting

• Used to develop and optimize purification methods prior to full production deployment

• Enables efficient method scaling to longer columns or continuous processes

• Supports consistent analytical → semi‑prep → prep → production workflows

Reliable Hydrophobic Retention

• Strong reversed‑phase retention for hydrophobic and neutral compounds

• Excellent for lipids and long‑chain fatty acids

• Provides greater retention than C8 phases

USP Method Compatibility

• Suitable for USP L1 methods

• Reliable for validated and regulated environments

• Supports method transfer across all HPLC scales

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances performance for challenging analytes

High Purity Silica

• Consistent chromatographic performance

• Reduced variability across runs and batches

Durable & Cost‑Efficient

• Long column lifetime

• Designed for high‑load production workflows

• Reduced downtime and maintenance frequency

Typical Applications

• Production‑scale purification

• Preparative method development

• Hydrophobic and neutral compound separations

• Pharmaceutical manufacturing

• Process scale‑up workflows

• USP L1 reversed‑phase methods

Important Usage Notes

• Designed for 30 mm production‑scale HPLC systems

• Requires very high‑flow capability and large sample loading volumes

• Ideal for fast screening prior to high‑purity production workflows

• Choose when loading capacity and robustness are prioritized over efficiency

Made‑to‑Order & Pricing Information

This is a custom, made‑to‑order item.

• Orders cannot be canceled once placed

• Custom items are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification:

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.