Catalog Number - 68018-P30-150

The 68018‑P30‑150 Cogent RP C18 Preparative HPLC Column is engineered for high‑resolution purification and production‑scale method development, utilizing 10 µm particles and fully double end‑capped C18 bonding to deliver robust performance, extremely high loading capacity, and durable chromatographic operation.

Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:

• Complete end‑capping to minimize silanol interactions

• Improved peak symmetry for polar and basic analytes

• Consistent and reproducible purification performance

This column is ideal as a USP L1 alternate and as a high‑performance platform for scaling purification processes into production workflows.

150 mm Length – Maximum Resolution for Production Purification

• Higher resolving power than 50 mm and 100 mm formats

• Maximizes peak capacity for complex mixtures

• Ideal for closely related compounds and difficult separations

• Preferred for final method refinement prior to full manufacturing runs

• Longer run times compared to shorter columns

This configuration is selected when maximum separation performance is required before production‑scale deployment.

30 mm ID – Maximum Production‑Scale Loading

• Provides extremely high sample loading capacity

• Designed for large‑scale purification and manufacturing workflows

• Supports very high‑flow preparative chromatography systems

Typical Flow Rate Range

• ~20–60 mL/min (system dependent)

• Optimize based on instrument capability and production requirements

✅ Designed for production‑scale HPLC systems capable of high flow rates and large injection volumes

Flow Rate & System Considerations (30 mm ID, 10 µm)

• Requires systems capable of:

  • Very high flow rates

  • Large injection volumes

• Compatible with:

  • Production preparative pumps

  • Large‑volume injection systems

  • High‑capacity fraction collection systems

⚠️ Not intended for analytical or semi‑prep HPLC systems

Why Choose RP C18 (10 µm, Production Scale)

Maximum Resolution for Production Workflows

• Ideal for final purification of complex mixtures at scale

• Maximizes separation performance and product purity

• Supports high‑purity manufacturing processes

Reliable Hydrophobic Retention

• Strong reversed‑phase retention for hydrophobic and neutral compounds

• Excellent for long‑chain fatty acids

• Provides greater retention than C8 phases

Method Development to Production

• Enables efficient method transfer from development to manufacturing

• Supports consistent performance across analytical → semi‑prep → prep → production workflows

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances performance for challenging analytes

High Purity Silica

• Consistent chromatographic results

• Reduced variability across runs and production batches

Durable & Cost‑Efficient

• Long column lifetime

• Designed for high‑load production workflows

• Reduced maintenance and replacement frequency

Typical Applications

• Production‑scale purification

• High‑purity compound isolation

• Complex mixture separations

• Pharmaceutical manufacturing and QC

• Process scale‑up and optimization

• USP L1 reversed‑phase methods

Important Usage Notes

• Designed for 30 mm production‑scale HPLC systems

• Requires very high‑flow capability and large sample loading volumes

• Ideal for maximum‑resolution purification workflows prior to final production runs

• Optimize for resolution vs throughput balance

Made‑to‑Order & Pricing Information

This is a custom, made‑to‑order item.

• Orders cannot be canceled once placed

• Custom items are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification:

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.