Catalog Number - 68018-P21-50

The 68018‑P21‑50 Cogent RP C18 Preparative HPLC Column is designed for method development and preparative scouting, utilizing 10 µm particles and fully double end‑capped C18 bonding to deliver reliable retention, high loading capacity, and durable chromatographic performance.

Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:

• Complete end‑capping to minimize silanol interactions

• Improved peak symmetry for polar and basic analytes

• Consistent and reproducible purification performance

This column is ideal as a USP L1 alternate and as a starting platform for preparative method development and analytical‑to‑prep scale‑up workflows.

50 mm Length – Fast Preparative Scouting

• Designed for rapid separations and short run times

• Ideal for early‑stage preparative method development

• Minimizes solvent consumption during screening

• Supports high‑throughput purification workflows

21.2 mm ID – High‑Capacity Preparative Scale

• Provides very high sample loading capacity

• Ideal for large‑scale purification and compound isolation

• Supports high‑flow preparative chromatography workflows

Typical Flow Rate Range

• ~10–30 mL/min (system dependent)

• Optimize based on instrument capability and application requirements

✅ Designed for preparative HPLC systems capable of high flow rates and large injection volumes

Flow Rate & System Considerations (21.2 mm ID, 10 µm)

• Requires systems capable of:

  • High flow rates

  • Large injection volumes

• Compatible with:

  • Preparative pumps

  • High‑volume injection systems

  • Fraction collection systems

⚠️ Not intended for analytical or semi‑prep HPLC systems

Why Choose RP C18 (10 µm, Preparative Scale)

Ideal for Preparative Scouting

• Used to develop and optimize methods prior to full‑scale purification

• Predictable selectivity for transition to longer columns and production scale

• Supports efficient analytical‑to‑preparative workflows

Reliable Hydrophobic Retention

• Strong reversed‑phase retention for hydrophobic and neutral compounds

• Excellent for long‑chain fatty acids

• Provides greater retention than C8 phases

Method Development & USP Compatibility

• Suitable for USP L1 methods

• Reliable for new and legacy workflows

• Supports method transfer and scale‑up consistency

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances performance for challenging analytes

High Purity Silica

• Consistent chromatographic performance

• Reduced variability across runs and batches

Durable & Cost‑Efficient

• Long column lifetime

• Designed for high‑load preparative workflows

• Reduced maintenance requirements

Typical Applications

• Preparative method scouting

• Large‑scale purification

• Hydrophobic and neutral compound separations

• Long‑chain fatty acids

• Analytical to preparative scale‑up workflows

• USP L1 reversed‑phase methods

Important Usage Notes

• Designed for preparative HPLC systems (21.2 mm ID)

• Requires high‑flow capability and large sample loading volumes

• Ideal for fast screening prior to scale‑up

• Choose when loading capacity and robustness are prioritized over efficiency

Made‑to‑Order & Pricing Information

This is a custom, made‑to‑order item.

• Orders cannot be canceled once placed

• Custom items are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification:

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.