Catalog Number - 68018-P21-150

The 68018‑P21‑150 Cogent RP C18 Preparative HPLC Column is engineered for high‑resolution purification and preparative method development, utilizing 10 µm particles and fully double end‑capped C18 bonding to deliver reliable retention, high loading capacity, and durable chromatographic performance.

Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:

• Complete end‑capping to minimize silanol interactions

• Improved peak symmetry for polar and basic analytes

• Consistent and reproducible purification results

This column is ideal as a USP L1 alternate and as a robust platform for preparative method development and scale‑up workflows.

150 mm Length – Maximum Resolution for Preparative Purification

• Higher resolving power than 50 mm and 100 mm formats

• Maximizes peak capacity for complex mixtures

• Ideal for closely related compounds and difficult separations

• Preferred for final purification and method refinement prior to production scale

• Longer run times compared to shorter columns

This format is selected when maximum separation performance is required before scaling to 250 mm or production workflows.

21.2 mm ID – High‑Capacity Preparative Scale

• Provides very high sample loading capacity

• Ideal for large‑scale purification and compound isolation

• Supports high‑flow preparative chromatography workflows

Typical Flow Rate Range

• ~10–30 mL/min (system dependent)

• Optimize based on instrument capability and purification requirements

✅ Designed for preparative HPLC systems capable of high flow rates and large injection volumes

Flow Rate & System Considerations (21.2 mm ID, 10 µm)

• Requires systems capable of:

  • High flow rates

  • Large injection volumes

• Compatible with:

  • Preparative pumps

  • High‑volume injection systems

  • Fraction collection systems

⚠️ Not intended for analytical or semi‑prep HPLC systems

Why Choose RP C18 (10 µm, Preparative Scale)

High‑Resolution Purification Platform

• Ideal for refining purification methods before final production scale

• Maximizes separation performance and product purity

• Supports efficient workflow from scouting to scale‑up

Reliable Hydrophobic Retention

• Strong reversed‑phase retention for hydrophobic and neutral compounds

• Excellent for long‑chain fatty acids

• Provides greater retention than C8 phases

USP Method Compatibility

• Suitable for USP L1 methods

• Reliable for validated and regulated workflows

• Supports method transfer and scale‑up consistency

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances performance for challenging analytes

High Purity Silica

• Consistent chromatographic performance

• Reduced variability across runs and batches

Durable & Cost‑Efficient

• Long column lifetime

• Designed for high‑load purification workflows

• Reduced maintenance requirements

Typical Applications

• Preparative purification

• Method development and refinement

• High‑purity compound isolation

• Complex mixture separations

• Pharmaceutical and QC workflows

• Analytical to preparative scale‑up workflows

• USP L1 reversed‑phase methods

Important Usage Notes

• Designed for preparative HPLC systems (21.2 mm ID)

• Requires high‑flow capability and large sample loading volumes

• Ideal for maximum‑resolution purification workflows prior to production scale

• Optimize for resolution vs throughput balance

Made‑to‑Order & Pricing Information

This is a custom, made‑to‑order item.

• Orders cannot be canceled once placed

• Custom items are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification:

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.