Catalog Number - 68018-15P-4

The 68018‑15P‑4 Cogent RP C18 HPLC Column is designed for method development and preparative scouting, utilizing 10 µm particles and fully double end‑capped C18 bonding to provide reliable retention, durability, and consistent chromatographic performance.

Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:

• Complete end‑capping to minimize silanol interactions

• Improved peak symmetry for polar and basic analytes

• Consistent and reproducible chromatography

This column is ideal as a USP L1 alternate and as a scouting platform for scaling analytical methods to preparative applications.

150 mm Length – Increased Resolution for Method Development

• Higher resolving power compared to 50 mm columns

• Improved separation of closely related compounds

• Increased peak capacity for method optimization

• Ideal for refining separations prior to preparative scale‑up

• Balanced between resolution and run time efficiency

This format is commonly selected when additional resolution is required beyond short scouting columns.

4.0 mm ID – Solvent‑Saving Analytical Format

• Comparable chromatographic behavior to 4.6 mm ID columns

• Reduces mobile phase consumption and waste

• Typical flow rate range: ~0.8–1.2 mL/min

• Optimal starting range: ~0.9–1.1 mL/min

Benefits:

• Lower solvent cost

• Reduced waste generation

• Compatible with standard HPLC systems

Flow Rate & System Considerations (4.0 mm ID, 10 µm)

• Suitable for standard HPLC systems

• Supports higher flow rates relative to smaller particle sizes

• Well suited for:

  • Preparative method development

  • Sample loading studies

  • Robust screening workflows

Why Choose RP C18 (10 µm)

Ideal for Preparative Scouting

• Used to develop and optimize methods prior to scale‑up

• Predictable selectivity when transferring to larger ID preparative columns

• Supports efficient analytical‑to‑preparative method transition

Reliable Hydrophobic Retention

• Strong reversed‑phase retention for hydrophobic and neutral compounds

• Excellent for long‑chain fatty acids

• Provides greater retention than C8 phases

Method Development & USP Compatibility

• Suitable for USP L1 methods

• Ideal for new analytical or preparative method development

• Reliable and consistent stationary phase chemistry

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances performance for basic analytes

High Purity Silica

• Consistent chromatographic performance

• Reduced variability between runs

Durable & Cost‑Efficient

• Long column lifetime

• Ideal for repeated method development cycles

• Reduced maintenance frequency

Typical Applications

• Preparative method scouting

• Method development and optimization

• Hydrophobic and neutral compound separations

• Long‑chain fatty acids

• Analytical to preparative scale‑up workflows

• USP L1 reversed‑phase methods

Important Usage Notes

• Designed for method development and preparative scaling workflows

• Compatible with standard HPLC systems

• Ideal for increased resolution during method refinement

• Choose when loading capacity and robustness are prioritized over efficiency

Made‑to‑Order & Pricing Information

This is a custom, made‑to‑order item.

• Orders cannot be canceled once placed

• Custom items are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification:

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.