CUSTOM ITEM: HPLC Column, RP C18, 10um, 4.0mm ID x 100mm Length, 100A. Cogent Brand. 1 EA.
Additional Info:
The 68018‑10P‑4 Cogent RP C18 HPLC Column is designed for method development and preparative scouting, combining 10 µm particles with fully double end‑capped C18 bonding to deliver durability, reproducibility, and reliable retention.
Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:
Complete end‑capping to minimize silanol interactions
Improved peak symmetry for polar and basic analytes
Consistent and reproducible chromatographic performance
This column is ideal as a USP L1 alternate and a scouting tool for scaling analytical methods to preparative separations.
100 mm Length – Method Development & Increased Resolution
Higher resolving power than 50 mm scouting columns
Improved separation of closely related compounds
Increased peak capacity during method optimization
Ideal for refining analytical methods prior to scale‑up
This format is selected when additional resolution is needed beyond initial scouting conditions.
4.0 mm ID – Solvent‑Saving Analytical Format
Comparable chromatographic performance to 4.6 mm ID columns
Reduces mobile phase consumption and waste
Typical flow rate range: ~0.8–1.2 mL/min
Optimal starting range: ~0.9–1.1 mL/min
Benefits:
Lower solvent cost
Reduced waste generation
Compatible with standard HPLC systems
Flow Rate & System Considerations (4.0 mm ID, 10 µm)
Suitable for standard HPLC systems
Supports higher flow rates and increased sample loading
Well suited for:
Preparative method development
Sample loading studies
Robust screening workflows
Why Choose RP C18 (10 µm)
Ideal for Preparative Scouting
Commonly used to develop and optimize methods prior to preparative scale‑up
Predictable selectivity when transferring to larger ID preparative columns
Supports efficient analytical‑to‑preparative workflows
Reliable Hydrophobic Retention
Strong reversed‑phase retention for hydrophobic and neutral compounds
Excellent for long‑chain fatty acids
Provides greater retention than C8 phases
Method Development & USP Compatibility
Suitable for USP L1 methods
Ideal for new analytical or preparative method development
Reliable and consistent stationary phase chemistry
Cogent RP C18™ Advantages
Fully End‑Capped Surface
Minimizes secondary interactions
Improves peak symmetry
Enhances performance for basic analytes
High Purity Silica
Consistent chromatographic performance
Reduced variability between runs
Durable & Cost‑Efficient
Long column lifetime
Ideal for repeated method development use
Reduced maintenance frequency
Typical Applications
Preparative method scouting
Method development and optimization
Hydrophobic and neutral compound separations
Long‑chain fatty acids
Analytical to preparative scale‑up workflows
USP L1 reversed‑phase methods
Important Usage Notes
Designed for method development and preparative scaling workflows
Compatible with standard HPLC systems
Ideal for refining separations prior to scale‑up
Choose when loading capacity and robustness are prioritized over efficiency
Made‑to‑Order & Pricing Information
This is a custom, made‑to‑order item.
Orders cannot be canceled once placed
Custom items are non‑returnable