Catalog Number - 68018-10P

The 68018‑10P Cogent RP C18 HPLC Column is designed for method development and preparative scouting, utilizing 10 µm particles and fully double end‑capped C18 bonding to deliver reliable retention, durability, and consistent chromatographic performance.

Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:

• Complete end‑capping to minimize silanol interactions

• Improved peak symmetry for polar and basic analytes

• Consistent and reproducible chromatography

This column is ideal as a USP L1 alternate and serves as a starting platform for analytical method development and scale‑up to preparative separations.

100 mm Length – Method Development & Increased Resolution

• Higher resolving power than 50 mm scouting columns

• Improved separation of closely related compounds

• Increased peak capacity during method optimization

• Ideal for refining separations prior to preparative scale‑up

This format is commonly selected when additional resolution is needed beyond initial screening methods.

4.6 mm ID – Standard Analytical Performance

• Industry‑standard HPLC column dimension

• Compatible with all conventional HPLC systems

• Typical flow rate range: ~0.8–1.5 mL/min

• Optimal starting range: ~1.0–1.2 mL/min

Provides:

• Strong detector response

• Reliable reproducibility

• Easy method transfer between systems and laboratories

Flow Rate & System Considerations (4.6 mm ID, 10 µm)

• Suitable for standard HPLC systems

• Supports higher flow rates and increased sample loading

• Well suited for:

  • Preparative method development

  • Analytical screening with higher loading

  • Scale‑up method optimization

Why Choose RP C18 (10 µm)

Ideal for Preparative Scouting

• Used to develop and optimize methods prior to preparative scale‑up

• Predictable selectivity when transferring to larger ID preparative columns

• Supports efficient analytical‑to‑preparative workflows

Reliable Hydrophobic Retention

• Strong reversed‑phase retention for hydrophobic and neutral compounds

• Excellent for long‑chain fatty acids

• Provides greater retention than C8 phases

Method Development & USP Compatibility

• Suitable for USP L1 methods

• Ideal for new analytical and preparative method development

• Consistent and dependable stationary phase chemistry

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances performance for basic analytes

High Purity Silica

• Consistent chromatographic performance

• Reduced variability between runs

Durable & Cost‑Efficient

• Long column lifetime

• Ideal for repeated method development

• Lower maintenance frequency

Typical Applications

• Preparative method scouting

• Method development and optimization

• Hydrophobic and neutral compound separations

• Long‑chain fatty acids

• Analytical to preparative scale‑up workflows

• USP L1 reversed‑phase methods

Important Usage Notes

• Designed for method development and preparative scaling workflows

• Compatible with standard HPLC systems

• Ideal for refining separations prior to scale‑up

• Choose when robustness and loading capacity are prioritized over efficiency