Catalog Number - 68018-05P

The 68018‑05P Cogent RP C18 HPLC Column is designed for method development and preparative scouting, utilizing 10 µm particles and fully double end‑capped C18 bonding to deliver reliable retention, durability, and consistent chromatographic performance.

Manufactured using high‑purity silica with traditional octadecylsilane (C18) bonding, this stationary phase provides:

• Complete end‑capping to minimize silanol interactions

• Improved peak symmetry for polar and basic analytes

• Consistent and reproducible chromatography

This column is ideal as a USP L1 alternate and as a scouting platform for scaling analytical methods to preparative separations.

50 mm Length – Fast Method Development

• Designed for rapid separations and short run times

• Ideal for early‑stage method screening and optimization

• Reduces solvent usage during method development

• Excellent for high‑throughput scouting workflows

4.6 mm ID – Standard Analytical Performance

• Industry‑standard HPLC column dimension

• Compatible with all conventional HPLC systems

• Typical flow rate range: ~0.8–1.5 mL/min

• Optimal starting range: ~1.0–1.2 mL/min

Provides:

• Strong detector response

• Reliable reproducibility

• Easy method transfer across laboratories

Flow Rate & System Considerations (4.6 mm ID, 10 µm)

• Suitable for standard HPLC systems

• Supports higher flow rates and increased sample loading

• Well suited for:

  • Preparative method scouting

  • High‑loading analytical studies

  • Robust screening workflows

Why Choose RP C18 (10 µm)

Ideal for Preparative Scouting

• Used to develop and optimize methods prior to scale‑up

• Predictable selectivity for transition to larger preparative columns

• Supports efficient analytical‑to‑preparative workflows

Reliable Hydrophobic Retention

• Strong retention for hydrophobic and neutral compounds

• Excellent for long‑chain fatty acids

• Provides greater retention than C8 phases

Method Development & USP Compatibility

• Suitable for USP L1 methods

• Ideal starting point for new analytical and preparative methods

• Consistent and dependable stationary phase chemistry

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances performance for basic analytes

High Purity Silica

• Consistent chromatographic performance

• Reduced variability between runs

Durable & Cost‑Efficient

• Long column lifetime

• Ideal for repeated method development use

• Lower maintenance frequency

Typical Applications

• Preparative method scouting

• Method development and optimization

• Hydrophobic and neutral compound separations

• Long‑chain fatty acids

• Analytical to preparative scale‑up workflows

• USP L1 reversed‑phase applications

Important Usage Notes

• Designed for method development and preparative scaling workflows

• Compatible with standard HPLC systems

• Ideal for fast screening prior to scale‑up

• Choose when loading capacity and robustness are prioritized over efficiency