Catalog Number - 68004-10P

Cogent RP C4 Butyl is a reversed-phase HPLC stationary phase manufactured using high-purity silica with traditional butyl (C4) ligand bonding and complete double endcapping. Classified as USP L26, this stationary phase provides moderate hydrophobic retention and is well suited for compounds that may be overly retained on more hydrophobic phases such as C8 or C18 columns. The C4 chemistry offers reliable selectivity for hydrophobic and neutral analytes while maintaining shorter retention times than longer alkyl-chain phases.

68004-10P is a 100 mm x 4.6 mm ID analytical HPLC column packed with 10 µm RP C4 Butyl particles featuring a 100 Å pore size. The 100 mm length provides an effective balance between analysis speed and chromatographic resolution, making it suitable for routine analytical testing, method development, and preparative method scouting. The 10 µm particle size supports higher flow rates with lower operating backpressure, while the 4.6 mm ID format is the industry standard for conventional HPLC systems and typically operates at approximately 1.0–2.0 mL/min.

This USP L26 column is particularly useful for hydrophobic and neutral compounds requiring less retention than a C8 phase. The combination of fully endcapped C4 chemistry, high-purity silica, and larger particle size provides robust chromatographic performance and excellent method flexibility for analytical and preparative workflow development.

Key Benefits

• RP C4 Butyl stationary phase

• USP L26 classification

• Fully double endcapped chemistry

• Traditional butyl (C4) bonded phase

• High-purity silica support

• 10 µm particles for lower backpressure

• Suitable for higher flow rates

• Less retention than C8 columns

• Balanced speed and resolution with 100 mm length

• Useful for preparative method scouting

Typical Applications

• Reversed-phase HPLC

• USP L26 methods

• Hydrophobic compound analysis

• Neutral compound analysis

• Method development

• Preparative method scouting

• Screening studies

• Quality control testing

• Higher flow rate applications

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP C4 Butyl

• USP Classification: L26

• Chromatography Mode: Reversed Phase

• Bonded Phase: Butyl (C4)

• Endcapping: Fully Double Endcapped

• Particle Size: 10 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 100 mm

• Length: 100 mm

• Recommended Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Important Notes

• Designed for reversed-phase chromatography

• Provides less retention than comparable C8 columns

• Suitable for hydrophobic and neutral compounds

• Larger particle size reduces operating backpressure

• Excellent choice for method development and preparative method scouting

• Compatible with conventional HPLC systems

• Alternative for many USP L26 methods