Catalog Number - 58846-06

58846-06 ARE‑Applied Research Mobile Phase Inlet Filter is a high‑performance, biocompatible solvent filtration device engineered for HPLC, UHPLC, and LC‑MS mobile phase delivery systems, providing maximum solvent recovery, very high flow capacity, and dependable system protection.

This filter features an advanced “Last Drop” flat‑profile design, enabling near‑complete withdrawal of mobile phase from reservoir bottles—ideal for long analytical runs, overnight sequences, and high‑volume solvent workflows.

Constructed with a 5 µm PTFE filter element and an inert PEEK / PTFE wetted flow path, this inlet filter delivers excellent chemical compatibility, low extractables, and stable performance, even in demanding environments.

“Last Drop” Design – Maximum Solvent Utilization

• Flat bottom‑draw filter geometry

• Optimized to sit at the lowest point in the bottle

• Draws solvent to near‑empty conditions

• Minimizes waste and prevents premature pump starvation

✅ Ideal for high‑flow systems, long sequences, and expensive solvents

✅ Improves efficiency and reproducibility of chromatographic runs

5 µm PTFE Element – High Flow / High Capacity Filtration

• Filters particles ≥ 5 µm

• Protects:

  • Pump seals and check valves

  • Injector systems

  • Columns and detectors

• Larger pore size provides:

  • Very high flow capacity

  • Low restriction / minimal backpressure

  • Extended service life

✅ Ideal for high‑flow applications or pre‑filtered mobile phases

Visual Inspection Advantage – White Filter Element

• White PTFE surface allows easy visibility of trapped particles

• Enables rapid assessment of contamination

• Helps determine optimal replacement timing

✅ Supports proactive maintenance and consistent solvent delivery

PEEK / PTFE Flow Path – High Purity Performance

• All wetted components made from:

  • PEEK (polyether ether ketone)

  • PTFE (inert fluoropolymer)

• Provides:

  • Chemical inertness

  • Low extractables and leachables

  • Broad solvent compatibility

✅ Suitable for LC‑MS, analytical, and biocompatible workflows

1/8" Connector with ETFE Ferrule – High‑Flow Integration

• Integrated 1/8" tubing connector

• Includes ETFE ferrule for non‑flanged tubing

• Provides secure, leak‑free connection

• No additional fittings required

✅ Ideal for higher flow rate systems and larger tubing configurations

Performance Advantages – Modern HPLC Operation

Compared to smaller pore inlet filters:

• Significantly lower flow resistance

• Improved solvent delivery stability at higher flow rates

• Reduced clogging risk

• Longer intervals between filter replacement

✅ Aligns with best practices for high‑efficiency and high‑flow chromatography systems

System Compatibility & Use

Designed for use with:

• HPLC / UHPLC mobile phase systems

• LC‑MS solvent delivery setups

• Low‑pressure tubing systems (1/8")

• Standard mobile phase reservoir bottles

✅ Installs directly into mobile phase bottles for inline solvent filtration

Typical Applications

• High‑flow HPLC mobile phase filtration

• LC‑MS solvent protection

• Pre‑filtered mobile phase systems

• Routine analytical workflows

• Extended and unattended chromatographic runs

• Integrated into original equipment manufacturer (OEM) product designs

Important Usage Notes

• Designed for low‑pressure systems only

• Ensure tubing is properly installed using the included ferrule

• Inspect filter element periodically for buildup

• Replace when flow decreases or restriction increases