HPLC Column, Diamond Hydride, 4 um, 2.1 mm ID x 100 mm Length, 100 A. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 70000‑10P‑2 Diamond Hydride HPLC Column is a narrow‑bore, extended‑length HILIC column engineered for applications that require greater chromatographic resolution while maintaining compatibility with LC‑MS and LC‑MS/MS systems.
Increased Resolution with Narrow‑Bore Efficiency
The 100 mm column length provides a longer interaction path between analytes and the stationary phase, delivering:
Improved separation of closely eluting polar compounds
Higher peak capacity compared to shorter column formats
Better analyte discrimination in complex sample matrices
The 2.1 mm internal diameter supports reduced flow rates, making this column particularly well suited for mass spectrometry detection, where solvent load and ionization efficiency are critical.
This size is often selected when:
A 50 mm column does not provide sufficient resolution
LC‑MS sensitivity and solvent control are priorities
Analysts want improved separation without moving to UHPLC particle sizes
Diamond Hydride™ Stationary Phase Performance
Manufactured using Cogent TYPE‑C™ silica hydride technology, the Diamond Hydride stationary phase delivers:
Excellent selectivity for polar and moderately polar analytes
Faster equilibration than conventional bonded silica HILIC phases
Robust column lifetime and stable retention behavior
This chemistry is well established for the analysis of:
Polar and non‑polar peptides
Amino acids
Metabolites
Challenging small molecules analyzed under HILIC conditions
LC‑MS‑Optimized Design
At typical operating conditions, the 2.1 mm ID format:
Reduces solvent flow into the mass spectrometer
Enhances electrospray ionization efficiency
Helps maintain cleaner MS sources over extended sequences
For this reason, the 70000‑10P‑2 is a popular choice for LC‑MS workflows when increased chromatographic resolution is required, while still operating on standard HPLC platforms.
Practical Operation
Despite its extended length and enhanced resolving power, the 70000‑10P-2 delivers near‑UHPLC separation efficiency without requiring UHPLC‑rated pressures, making it a practical choice for laboratories seeking high resolution with existing instrumentation.
2.1 mm ID column system requirements:
Typical operating flow rates: ~0.2–0.3 mL/min
Requires an HPLC system capable of accurate, stable low‑flow delivery.
Not all standard HPLC pumps are suitable for reliable operation at these flow rates.