Catalog Number - 58022-PES25-K

The 58022-PES25-K AQ™ Syringe Filters are pharmaceutical-grade, high-throughput membrane filters engineered for HPLC sample preparation, sterile filtration, and dissolution testing in regulated laboratory environments. Featuring a 0.22 µm Polyethersulfone (PES) membrane, these filters deliver exceptional consistency, ultra-low protein binding, and extractable-free performance, ensuring maximum sample purity and reproducible analytical results in high-volume workflows.

The 0.22 µm pore size is optimized for sterile filtration and fine particulate removal, making these filters ideal for protein solutions, buffers, and culture media where analyte recovery and cleanliness are critical.

✅ Critical Compliance Advantage (No Flush Required)

These filters are validated and certified to meet stringent regulatory requirements, including:

• US FDA CFR Title 21, Part 211.92 for minimum fiber release

• USP <788> for particulate matter in injectables

• USP requirements for “Sterile Water for Injection”

Because of this validated performance:

• ✅ No initial flushing is required

• ✅ No need to discard the first 200 µL of filtrate

• ✅ Preserves valuable samples (critical for protein recovery)

• ✅ Eliminates a common source of failed methods and costly investigations

👉 This delivers a major operational and compliance advantage for QC/QA and biopharmaceutical laboratories, particularly in regulated, high-throughput environments.

Performance & Design

The 0.22 µm PES membrane provides reliable sterile filtration with ultra-low protein binding, ensuring maximum recovery of biomolecules and sensitive analytes.

PES membrane chemistry offers excellent flow rates, low extractables, and minimal adsorption, making it ideal for protein solutions, buffer systems, and biological samples.

These filters provide absolute retention and low hold-up volume, supporting accurate quantitation, minimal sample loss, and high reproducibility in critical workflows.

The 25 mm format supports higher sample volumes and high-throughput laboratories, while the bulk 1000/case packaging is ideal for production-scale, QC, and routine analytical environments.

The white housing with red lettering enables quick identification of 0.22 µm PES filters, and each case includes a Certificate of Analysis for full traceability and compliance.

Key Features

0.22 µm PES Membrane (Pharma Grade)

• Ideal for sterile filtration and fine particulate removal

• Ensures maximum sample clarity and system protection

✅ No Initial Flush Required (Validated)

• Extractable-free from first filtrate

• No 200 µL discard required

Ultra-Low Protein Binding

• Maximizes recovery of proteins and biomolecules

• Ideal for biopharma and biological applications

High Throughput Performance

• Fast filtration with minimal resistance

• Suitable for high-volume workflows

Low Extractables

• Ensures clean chromatographic baselines

• Improves reproducibility

Absolute Retention

• Reliable sterile filtration performance

• Suitable for critical analytical methods

Regulatory Compliance

• Meets FDA CFR 21 (211.92) requirements

• Complies with USP <788>

• Suitable for Sterile Water for Injection

25 mm Diameter for High Throughput

• Handles larger volumes

• Improves lab productivity

Autoclavable & EO Sterilizable

• 121°C for 30 minutes or Ethylene Oxide

Color-Coded (White / Red)

• Identifies 0.22 µm PES filters

Bulk Packaging (1000/Case)

• Reduces cost per analysis

• Ideal for high-throughput labs

Typical Applications

• HPLC & UHPLC Sample Preparation – fine particulate removal prior to injection

• Sterile Filtration – bacterial and contaminant removal

• Protein & Biomolecule Filtration – low binding, high recovery

• Cell Culture Media & Buffers – clean and efficient filtration

• Dissolution Testing – pharmaceutical QC workflows

• Biopharmaceutical Analysis – sensitive sample recovery

• High-Throughput QC Labs – consistent, efficient performance

Specifications

• Filter Type: Syringe Filter (Pharma Grade)

• Membrane Material: PES (Polyethersulfone)

• Pore Size: 0.22 µm

• Diameter: 25 mm

• Housing Material: Polypropylene (PP)

• Color Code: White / Red (0.22 µm PES)

• Connection Type: Luer Lock / Slip

• Chemical Compatibility: Aqueous solutions, buffers, biological samples

• Protein Binding: Ultra-low

• Extractables: None detectable (no flush required)

• Sterilization: Autoclave or EO

• Compliance: FDA CFR 21 (211.92), USP <788>

• Certification: Certificate of Analysis included

• Sterility: Non-sterile

• Pack Size: 1000/Case

• Brand: AQ™

Resources & Ordering Options

• Order PES syringe filters, 0.22 µm, 25 mm – 100/pack quantity

• Purchase PES syringe filters, 0.22 µm, 25 mm – 50/pack quantity