An NMDA Receptor Antagonist for Alzheimer’s Disease

This simple isocratic Method requires no use of derivatization or other additives for keeping the peak shape of this Tricyclic Amine symmetrical.  This Method displays excellent Repeatability of the data with %RSD values of <0.12 for the Retention Times.

1. Diluent
2. Memantine HCL

Method Conditions:
Column: Cogent Diamond Hydride™, 4μm, 100Å
Catalog No.: 70000-10P
Dimensions: 4.6 x 100mm
Mobile Phase:  95% Acetonitrile with 10mM Ammonium Formate
Injection vol.: 1μL
Flow rate: 1.0mL / minute
Detection: ELSD (Evaporative Light Scattering Detector)
Temperature: 50°C
Gain: 12
3.5 bar Nitrogen 
Sample Preparation: Memantine HCL 0.1mg / mL in DI Water

Note: Memantine is used to treat moderate to severe confusion (dementia) related to Alzheimer’s disease. Memantine blocks the effects of glutamate, a neurotransmitter in the brain that leads to neuronal excitability and excessive stimulation in Alzheimer’s Disease