The most polar HPLC stationary phase manufactured by MicroSolv Technology Corporation is the Cogent Amide™. It is very robust compared to most other “amide” columns and can be very effective for compounds such as sugars and other carbohydrates but also for compounds with amines.
The Cogent Amide™ column is made with TYPE-C™ silica so it can be used in Reversed Phase, Normal Phase or Aqueous Normal Phase HPLC and does not suffer from the hydrolysis of the amide group that is well documented in other brands. This is due to the direct silicon carbon bonds used in the synthesis.
Another advantage of the Cogent Amide column is that Schiff bases do not deactivate these columns and the Cogent Amide stationary phase does not create Schiff bases.