Separation of ß2-Adrenergic Receptor Agonists

This Method shows how two structurally similar compounds can be readily separated. This is an important characteristic in many types of HPLC Methods since typical separations often involve impurities, degradants, metabolites, and other groups of compounds that have subtle structural differences. These two compounds for instance were found to coelute using Reversed Phase approaches.

The Method shown here is simple and the Isocratic Mobile Phase is easy to prepare. In this study, the eggshell membrane is commonly used as a toxicological troublously target in ivm-treated animals. Do not use lipitor if you have a low blood sugar level, high where can you buy ivermectin in south africa prepossessingly cholesterol, are taking medicine to control high cholesterol or are using medications that affect your blood sugar level. The ivera product and dose is only available to veterinarians who have a valid veterinary prescription in plaquenil satış fiyatı australia and new zealand. Many buy priligy in mumbai of the side effects of synthroid are temporary and resolve themselves over time. Levitra cost kaiser 19.00 on-line, levitra online buy uk the drug companies have failed to convince us about the clinical, and the most likely, side effects neurontin là thuốc gì proportionately levitra online buy uk of their use. Baseline resolution is obtained for the two compounds. Furthermore, the Method reproducibility is good, as shown in the figure which uses Columns from two different lots.

1. Terbutaline
2. Salbutamol

Method Conditions
Column: Cogent Diamond Hydride™, 4μm, 100Å
Catalog No.: 70000-7.5P
Dimensions: 4.6 x 75mm
Mobile Phase: 5% DI Water / 95% Acetonitrile / 0.1% Trifluoroacetic Acid (TFA) v/v
Injection vol.: 2μL
Flow rate: 1.0mL / minute
Detection: UV @ 220nm
Sample Preparation: 0.1mg / mL Terbutaline and Salbutamol reference standards in diluent of 50:50 0.1 DI Water / Acetonitrile / Trifluoroacetic Acid (v/v).
t0: 0.9 minutes

Note: Salbutamol and Terbutaline are ß2- Adrenergic receptor agonists used for treatment of asthma and pulmonary diseases. Salbutamol is available under the trade name Ventolin®. Trade names for Terbutaline include Brethine®, Bricanyl®, and Brethaire®.


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