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Syringe Filters

16 If I use one syringe filter for many samples will I get sample carry over?

You will most likely get some kind of carry over. It is not recommended to use one filter for more than one sample. Reusing the same syringe filters for multiple samples is never recommended due to carry…

17 Sometimes I see extra peaks in my samples and sometimes I am not using the same filter. Do you have any ideas?

Yes, the “proper” way to use any syringe filter is to dispose of the first few milliliters that comes from the filter. If there are any extractables or if there is going to be any adsorption to the…

18 Spurious Peaks from nylon syringe filters with a DI water solvent with Electrochemical Detection.

When using electrochemical detection, spurious peaks in your chromatogram may be observed if a nylon syringe filter is used with a DI water solvent. The anionic peaks are most likely nitrate extractable…

19 What are the differences between Nylon and PTFE filters for my filtration application?

There is a bit of a misconception in the field regarding PTFE v. Nylon membranes for filtration using syringe filter devices and which membrane can be used with different solutions and or sovlents. PTFE…

20 What is a “steady state” for filters?

A filter could have charged sites on it or a small amount of extractables. Most manufacturers, including MicroSolv, produce filters with the lowest extractables possible. If these extractables are soluble…

21 What is an extractable that comes from syringe filters?

An extractable from a syringe filter or any device for that matter, is any chemical that is present in your sample after filtering that was not there before and the source is the filter. Most of the time,…

22 What is the difference between a Luer Lock and a Luer Slip Connector?

When using a device such as a syringe filter and a syringe which has a Luer slip connector on it, the device will simply slide onto the tip of the syringe. If it is applied properly (fully placing the…

23 What is the difference between AQ™ brand and low cost syringe filter brands?

AQ™ syringe filters are made to a higher standard of quality such as extractables, adsorption, flow design and have a 3 piece leak proof plastic device. AQ™ filters are supplied with CofA for HPLC…

24 What is the maximum sample volume for a 25mm AQ syringe filter?

You can use up to 100ml in a single 25mm syringe filter is you are using an aqueous solvent and your sample is not cloudy. However, the best way to determine if the filter should be replaced is when you…

25 What product traceability does MicroSolv provide for its syringe filters? Do you retain samples from each lot?

All MicroSolv syringe filters have lot numbers which can be followed to complete traceability to the raw materials used in manufacturing the filters. We have a mandatory 3 year archive time of samples…

26 Which membrane is best for aqueous buffers when using syringe filters?

The best membrane is a difficult question to answer as it depends on your sample that you are filtering and the solvent is it dissolved in. For most HPLC and Dissolution testing, hydrophilic Nylon membranes…

27 Which solvents should I avoid with syringe filters with a Nylon membrane?

Aldehydes and strong acids such as hydrochloric and nitric should be avoided. Syringe Filters Information © Copyright MicroSolv Technology Corporation, all rights reserved.

28 Why is filtering of water samples very slow when using PTFE membrane filters?

PTFE is very hydrophobic and therefore not well-suited to aqueous-based samples. Due to the polarity difference, it will be difficult to filter. Nylon is more hydrophilic and should be used for water-based…

29 Will I protect my columns from samples that permanently adsorb to them by using a syringe filter?

No, some lab people get confused on the purpose of syringe filters. They are not chemical filters, only particulate filters and only remove un-dissolved particles from your filtrate. If anything is dissolved…

30 Will I see any differences in my chromatography if I use your syringe filters?

If you use proper techniques, you should not see any differences in your chromatography, CE or UV testing. Syringe filters only protect your equipment and columns and never participate in separations…

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