||Equivalency study of syringe filters in situ
An unbiased study was conducted by a pharmaceutical company that compared market leading brands of syringe filters in situ to the MicroSolv AQ™ syringe filters. The results were that MicroSolv AQ™…
||Are AQ brand nylon syringe filters compatible with DMSO?
Yes, the MicroSolv AQ™ brand of syringe filters are made with a polypropylene housing which is DMSO compatible. Our nylon membranes, both 0.45um and 0.22um are fully compatible with solutions containing…
||Are nylon filters compatible with chloroform?
All nylon filters are not recommended for use with halogenated solvents such as chloroform or with strong acids (1N and stronger). For these liquids, you should consider using PTFE filters. View filtration…
||Are the MicroSolv AQ brand of syringe filters membranes supported by extra membranes in the plastic housing device?
The PTFE (Teflon) syringe filter membranes are backed with a polypropylene support all the others including Nylon, Regenerated Cellulose, Cellulose Acetate and PVDF are not. Syringe Filters Information…
||Are the MicroSolv AQ syringe filters sterile?
No, but on special order we can supply our syringe filters in individual blister packs and can be sterilized. Depending on the membrane, the sterilization could be autoclaving or radiation. . Syringe…
||Are the MicroSolv AQ™ brand syringe filters bi-directional in their flow?
Yes, all the filters are bidirectional except PTFE and those that have pre-filters for aqueous solutions. Although in a syringe filter format the flow in two directions may not be equivalent because of…
||Can I autoclave chromatography syringes?
Yes, the chromatography syringes are fully compatible in an autoclaving application. If you are using the syringes with membrane filters, please verify that the filter is also suitable for the autoclaving…
||Can I autoclave the MicroSolv AQ brand 25mm PTFE syringe filters?
Yes, under conditions of 121 C for a maximum of 15minutes, the PTFE filters can be autoclaved. Maximum operating temperature (continuous) we suggest that you do not exceed 80 C to maintain optimum performance.…
||Can I make the PTFE syringe filter more hydrophilic?
Yes, if you are wiling to introduce Methanol into your method. For a 25mm device, if you use 15-20mls of methanol as a blank filtrate, the membrane will give you less back pressure after that for aqueous…
||Changing analyte recovery when using syringe filters
Question: I am doing a sunscreen analysis which requires that the sample solution is filtered. My diluent is 95/5 methanol/DI water and I am using MTC 0.45um nylon syringe filters. One day I observe consistent…
||I am seeing a loss in concentration of heparin with HPLC when using syringe filters. What do you recommend?
Heparin has strongly acidic sulfonate groups (negatively charged) that will bind with nylon filter membrane material. PTFE is not suitable because of its hydrophobicity. The most appropriate membrane…
||I use normal phase chromatography, which syringe filter do you recommend?
PTFE is the best for use with non polar, organic solvents required for normal phase chromatography. You should also consider using Aqueous Normal Phase chromatography if possible. See link below. Syringe…
||If I use one syringe filter for many samples will I get sample carry over?
You will most likely get some kind of carry over. It is not recommended to use one filter for more than one sample. Reusing the same syringe filters for multiple samples is never recommended due to carry…
||Sometimes I see extra peaks in my samples and sometimes I am not using the same filter. Do you have any ideas?
Yes, the “proper” way to use any syringe filter is to dispose of the first few milliliters that comes from the filter. If there are any extractables or if there is going to be any adsorption to the…
||Spurious Peaks from nylon syringe filters with a DI water solvent with Electrochemical Detection.
When using electrochemical detection, spurious peaks in your chromatogram may be observed if a nylon syringe filter is used with a DI water solvent. The anionic peaks are most likely nitrate extractable…