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MicroSolv manufactures HPLC columns, autosampler vials for HPLC & GC, syringe filters, fittings and accessories and small bore tubing. CE, TLC, Flash Chromatography and OPLC are also available. Separation sciences leaders.

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Applications for RP Reversed Phase HPLC

1 (l)-9-Carboxy-11-Nor-Delta-9- tetrahydrocannabinol

THC metabolite in urine matrix Discussion The extraction procedure using an SPE technique allows for successful detection of this cannabis metabolite with the Cogent Phenyl Hydride™ column. It is worth…

2 β-Carotene Capsule

Separation from other matrix peaks Discussion Beta-carotene may be taken as a dietary supplement in capsule form. In this case, a wide variety of matrix peaks were observed in the chromatographic data.…

3 1,4-Benzodiazepines in Urine

LC-MS method with SPE Discussion The Cogent Diol™ column was used in analysis of 1,4-benzodiazepines in urine samples after SPE extraction using two types of retention modes. Four available compounds…

4 10 Phenolic Compounds Separated

Commercial Rice Extract Discussion Commercial rice extract 3 was spiked with ten standards and analyzed. The Cogent Phenyl Hydride™ column was an excellent choice to use for analysis of phenolic compounds…

5 4’-Aminoacetophenone: Drug Metabolite

4’-aminoacetophenone Discussion The use of a Cogent Bidentate™ C18 column in RP-HPLC mode was investigated using 4’-acetaminophenone as a model compound. The short column gave adequate retention…

6 5 Phenolic Compounds Separated

Commercial Rice Extract Discussion A commercial rice extract was analyzed using the Cogent Phenyl Hydride™ column and peaks were assigned based on retention times and m/z values for the compounds of…

7 A Generic Method Development Strategy: Aqueous Reverse Phase (ARP), Aqueous Normal Phase (ANP) & Organic Normal Phase (ONP)

Choose Polarity or Functionality as the Main Selectivity Factor on the Same Column Discussion Chromatogram A ARP- Reverse Phase: Loratadine in 100% THF elutes with the solvent front. With 70% Aqueous/…

8 Acetaminophen & impurity

Drug Substance by HPLC Discussion A high-performance liquid chromatography (RP-HPLC) method has been developed for determination of acetaminophen: drug substance. The chromatographic separation was achieved…

9 Acetaminophen Impurities Method

Robust, Easy, APAP Method Discussion Acetominophen and two of its major impurities were analyzed using the Cogent Bidentate C18™ column and a simple mobile phase. The peak shapes were very high. The…

10 Amoxicillin (USP Method)

Robust USP Assay Analysis Discussion The USP assay method for amoxicillin often yields poor peak shapes and low method reproducibility with L1 columns based on type B silica. In contrast, the figures…

11 Analgesic Drugs

Excellent Peak Shapes Discussion A robust and rapid method was developed for the accurate simultaneous determination of 2 analgesics (Paracetamol, Aspirin), caffeine, internal standard (benzoic acid),…

12 Analysis of Alpha and Beta-Acids in Hops

Robust, precise method for beer samples Discussion The effectiveness of the presented method is evident from the fact that data obtained were in a good agreement with the literature values. This method…

13 Analysis of MDMA in plasma

Using Phenyl Hydride column Discussion Under the described conditions, MDMA was retained and eluted as a symmetrical peak. The sensitivity of the method is very good and comparable to that reported with…

14 Aspirin & Salicylic Acid

Excellent Peak Shape For a Very Difficult Compound Discussion This method is easy to prepare, use and reproduce a good separation of aspirin from its major hydrolysis product, salicylic acid. Note the…

15 Atorvastatin forced degradation

Separation of API from its lactone degradation product Discussion Atorvastatin is separated from its main degradation product using a Bidentate C18 column and a simple linear reversed phase gradient.…

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