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Comparison of 4 μm vs. 2.o™ Columns in Analysis of Drospirenone/Ethinyl Estradiol Tablet

Reference Number: AA-02646 Created: 06/02/2015 08:07 PM Last Updated: 06/07/2017 11:59 AM

Easy method transfer from 4µm to 2.o™

Discussion


The Bidentate C18™ is an excellent choice for reversed phase applications. In addition to the standard 4µm material, a near-UHPLC 2.o™ phase is also available. These 2.2µm columns provide inherently superior efficiency than a larger particle size. Because the same C18 ligand is used in both phases, method transfer is an easy process due to comparable retention times obtained between the two phases. These properties are explored and discussed in this intriguing application. A mixture consisting of drospirenone and ethinyl estradiol (Ocella® tablet) was used to illustrate these advantages. In this example, the advantage of the higher efficiency is demonstrated by the presence of low-level peaks. These are more clearly defined using the 2.o™ phase, thereby improving detection and quantitation.

1.Ethinyl Estradiol
2.Drospirenone
3.Impurity

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No 339 Comparison of 4 μm vs.2.o Columns in Analysis of Drospirenone Ethinyl Estradiol Tablet.pdf 0.4 Mb Download File
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