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Bisphenol A Extended Application Note

Reference Number: AA-02601 Created: 04/13/2015 10:39 AM Last Updated: 04/13/2015 10:46 AM

Bisphenol A is a synthetic compound used in a variety of consumer products, such as CDs, water bottles, and water pipe linings. Despite having many uses in these products, there has been some concern in recent years that exposure to BPA may have adverse health implications. BPA is believed to act as an endocrine disruptor by mimicking the metabolic action of estradiol. With current studies, it remains to be determined just how harmful BPA actually is. What is certain is that, due to its ubiquity in modern society, BPA is detectable in approximately 90% or more of the U.S. population.
     Infants and young children are thought to be at the greatest risk from BPA exposure since the metabolic detoxification pathway used to remove it from the body is not fully developed. For this reason, BPA was banned from baby bottles in the U.S. However, the FDA does not consider it to be a significant health threat to adults, although their findings continue to be challenged by new studies.
     If a more definitive conclusion regarding the health effects of BPA is to be reached, then reliable analytical methods will be needed to aid in future studies. Here we present the use of the Cogent Bidentate C8™ column for HPLC analysis of two BPA-containing materials. The column is well-suited to reversed phase analysis of hydrophobic compounds such as BPA. The stationary phase surface is virtually free of silanols, which allows for very fast equilibration between injections. For the gradient runs investigated here, only 1 minute equilibration time was required. The column is also versatile in that excellent data can be obtained using different BPA-containing samples as well as extraction procedures.


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