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How do I calculate assay of lisinopril dihydrate based on the anhydrous form?

Reference Number: AA-01288 Created: 03/20/2013 11:09 AM Last Updated: 03/20/2013 11:17 AM

When you weigh your reference standard and use the mass in the assay calculations of your formulation, you must correct for the water since the reference standard is the dihydrate form. You know the molecular weight of lisinopril and of the two H2O molecules so you would apply a mass correction factor of M.W. anhydrous form/ M.W. dihydrate form. Using this gives the mass of anhydrous lisinopril in the reference standard portion that was weighed.

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