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MicroSolv manufactures HPLC columns, autosampler vials for HPLC & GC, syringe filters, fittings and accessories and small bore tubing. CE, TLC, Flash Chromatography and OPLC are also available. Separation sciences leaders.

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Clopidogrel Forced Degradation

Reference Number: AA-00805 Created: 05/17/2012 04:25 PM Last Updated: 07/12/2013 12:20 PM

LC-MS Compatible Separation of API from Degradants  


Although clopidogrel, commonly known as Plavix®, retains well in reverse phase, its degradants showed low retention even at high water content. Therefore a method using the Diamond Hydride™ column was used in which the compounds are retained on the basis of polarity. This method uses MS-compatible solvents and provides excellent retention and separation between the API and three observed degradants.
Clopidogrel is a widely prescribed antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. The U.S. patent for Plavix® is set to expire in May 2012.

No 166 Clopidogrel Plavix by LCMS in ANP.pdf 0.4 Mb Download File
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