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Citric, Aconitic & Maleic acids by ANP

Reference Number: AA-00747 Created: 05/15/2012 06:29 AM Last Updated: 07/12/2013 10:56 AM

Low Molecular Weight Organic Acids  

Discussion


Low molecular mass acids were retained and separated using a Cogent Diamond Hydride™ column in the Aqueous Normal Phase mode of HPLC LC-MS chromatography (ANP-LC-MS). The method described above was able to resolve three acids in 10 minutes.
     Limits of detection (LOD) for the 3 acids ranged from 0.05 to 24 microM. The disadvantages of current ion-exchange chromatography methods are the use of a strongly acidic cation exchanger which has low exchange capacity, the long time required for equilibrium, separation and re-equilibrium.

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No 64 Citric Acid by ANP on Diamond Hydride.pdf 0.9 Mb Download File
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