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Xanthine, Uric acid & Hypoxanthine determinations

Reference Number: AA-00679 Created: 05/09/2012 04:37 PM Last Updated: 07/12/2013 11:02 AM

From human fluids



A simple ANP method was developed for the determination of xanthine (X), uric acid (UA), and hypoxanthine (HX) at concentrations in human urine (can be used for human serum) to support pharmacodynamic (PD) studies of a novel xanthine oxidase inhibitor during its clinical development. PD biomarkers (UA, X, and HX) were well separated from each other. In addition xanthine was separated from two isobaric unknowns (unknown A and B) present in this particular urine sample. Current HPLC methods for UA/X/HX measurements suffer from low sensitivity, poor selectivity, and/or inefficient sample throughput. The developed ANP method is fast and sensitive and it will allow high sample throughput.

No 96 Xanthine, Uric Acid Human Fluids on DH in ANP.pdf 0.2 Mb Download File
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