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MicroSolv manufactures HPLC columns, autosampler vials for HPLC & GC, syringe filters, fittings and accessories and small bore tubing. CE, TLC, Flash Chromatography and OPLC are also available. Separation sciences leaders.

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Reference Number: AA-00639 Created: 05/01/2012 04:44 PM Last Updated: 09/09/2016 10:30 AM

Separation of potential urine biomarker from isobaric ß-alanine  


This developed LC-MS method can separate sarcosine from beta-alanine in serum and urine samples without using labor-intensive sample derivatization. Since sarcosine is considered a potential biomarker for prostate cancer risk and aggressiveness, it is essential to resolve and accurately quantify this compound in the presence of isobaric (same m/z) beta-alanine. This objective is achieved using a Cogent Diamond HydrideTM column and a simple gradient method presented in this application note. The developed method is sensitive, specific, quantitative, and reproducible (%RSD =0.1). It can be used in large scale studies with numerous samples (high throughput of the method due to simple sample preparation).

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