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Domoic Acid

Reference Number: AA-00638 Created: 05/01/2012 04:34 PM Last Updated: 07/12/2013 11:15 AM

Determination without derivatization


To date, several analytical methods have been developed for the quantitative determination of domoic acid (DA). However, many of the methods require tedious and labor-intensive derivatization of this compound in order to detect it. A new method based on HPLC and MS detection which does not require derivatization has been developed. A simple linear gradient and typical MS compatible mobile phases were used to retain DA, a potent neurotoxin. The advantage of using Cogent columns is that they equilibrate rapidly when a gradient is used. The method can be used by regulatory agencies responsible for monitoring the occurrence of toxins for analysis of domoic acid in seafood samples and other laboratories.

No 130 Determination of Domoic Acid without Derivitizing.pdf 76.9 Kb Download File
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