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Domoic Acid

Reference Number: AA-00638 Created: 05/01/2012 04:34 PM Last Updated: 07/12/2013 11:15 AM

Determination without derivatization

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To date, several analytical methods have been developed for the quantitative determination of domoic acid (DA). However, many of the methods require tedious and labor-intensive derivatization of this compound in order to detect it. A new method based on HPLC and MS detection which does not require derivatization has been developed. A simple linear gradient and typical MS compatible mobile phases were used to retain DA, a potent neurotoxin. The advantage of using Cogent columns is that they equilibrate rapidly when a gradient is used. The method can be used by regulatory agencies responsible for monitoring the occurrence of toxins for analysis of domoic acid in seafood samples and other laboratories.

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No 130 Determination of Domoic Acid without Derivitizing.pdf 76.9 Kb Download File
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